| METHOD OF PRODUCING NADROPARIN CALCIUM | |
| 2023-11-15 | |
| 专利权人 | PHARMBIOPROM LLC (PHAR-Non-standard) |
| 申请日期 | 2023-11-15 |
| 专利号 | RU2828258-C1; EA49054-B1 |
| 成果简介 | NOVELTY - Invention relates to a method of producing nadroparin calcium, in which sodium heparin is dissolved in water, cooled, pH of the solution is adjusted to 2.45–2.55 and sodium nitrite is added, then bringing the pH of the reaction mass to 9.9–10.7, after which sodium borohydride is added to the solution, then the pH of the reaction mass is brought to 3.8–4.0, after which the reaction mass is brought to pH 6.7–6.9, then ethyl alcohol is added to the solution, stirred and left until the oil settles, the solution is decanted, the remaining oil is stirred in ethyl alcohol until a solid friable precipitate is formed, which is filtered, sodium nadroparin is obtained, then dry sodium nadroparin is dissolved in a phosphate buffer solution and the solution is concentrated, ion exchange is carried out by passing the solution through a weakly acidic cationite to obtain an intermediate product, to which a suspension of calcium hydroxide is added, then pH is adjusted to 6.8 and the solution is evaporated, then calcium nadroparin is lyophilized. USE - Chemistry. ADVANTAGE - High output of low-molecular weight heparin due to high selectivity of its fractionation using ultrafiltration. 1 cl, 2 ex |
| IPC 分类号 | A61K-031/727 ; C08B-037/10 ; A61P-007/02 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19274 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | PHARMBIOPROM LLC (PHAR-Non-standard) |
| 推荐引用方式 GB/T 7714 | ALEKSANDROV A G,ALEKSANDROV G V,ARAKELOV S A,et al. METHOD OF PRODUCING NADROPARIN CALCIUM. RU2828258-C1; EA49054-B1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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