| METHOD OF PRODUCING CONJUGATES BASED ON CARBON NANOSTRUCTURES | |
| 2023-11-20 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2023-11-20 |
| 专利号 | RU2829735-C1 |
| 成果简介 | NOVELTY - Invention relates to a method of producing conjugates based on carbon nanostructures, characterized by a high content of oxygen-containing groups and which are graphene oxide, or carbon nanotubes, or nanodiamonds, or fullerene adducts containing carboxyl and/or hydroxyl and/or amino groups. Method involves dispersing carbon nanostructures in a solvent, which is water, or dimethyl sulfoxide, or water-dimethyl sulfoxide, then the obtained dispersion is treated with ultrasound for 15 minutes. Cross-linking agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide or 1,3-dicyclohexylcarbodiimide and 4-dimethylaminopyridine are added to the obtained dispersion, the obtained mixture is stirred for 90 minutes and a vector solution for targeted delivery is added. Obtained mixture is then stirred for 48 hours and centrifuged, after which the obtained conjugate is washed with ethanol, followed by drying, then it is dispersed in a phosphate-salt buffer. Cytotastic agent is added, and the obtained mixture is stirred for 72 hours, after which it is purified by dialysis against distilled water, followed by drying at temperature of 45 °C and pressure of 0.8 bar for 24 hours. USE - Chemistry. ADVANTAGE - Obtaining conjugates based on carbon nanostructures, having high capacity with respect to cytotoxic agents when loaded through non-valence interactions. 1 cl, 11 dwg, 4 ex |
| IPC 分类号 | C01B-032/152 ; C01B-032/158 ; C01B-032/198 ; C01B-032/25 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19226 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | SEMYENOV K N,YUREV G O,AGEEV S V,et al. METHOD OF PRODUCING CONJUGATES BASED ON CARBON NANOSTRUCTURES. RU2829735-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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