| METHOD FOR INCREASING EFFECTIVENESS OF IMMUNE CHECKPOINT INHIBITORS USING THERAPEUTIC COMPOSITION BASED ON INDOLE DERIVATIVES AND PROBIOTIC | |
| 2023-11-20 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2023-11-20 |
| 专利号 | RU2826495-C1 |
| 成果简介 | NOVELTY - Invention is aimed at increasing the anti-tumor efficacy of immunotherapy with programmed cell death receptor 1 (PD-1) inhibitors. Method of increasing the effectiveness of PD-1 inhibitors involves administering a low-molecular compound indole-3-propionate and a probiotic based on microorganism strains Lacticaseibacillus paracasei subsp. paracasei 29n_21 (registration number VKM B-3711D) and Bifidobacterium longum subsp. longum 202/21 (registration number VKM B-3717D), wherein indole-3-propionate and probiotic agent are not mixed before introduction. Indole-3-propionate is administered in the form of a solution containing up to 4% ethoxylated castor oil and suitable for oral or intravenous administration, wherein the dose of indole-3-propionate in the form of a solution for single oral and intravenous administration should not exceed 400 mg/kg, and for multiple administration, the total course dose should not exceed 400 mg/kg. One dose of the probiotic agent contains lacto-N-biose, chitosan, 7×107 CFU Lactobacillus paracasei subsp. paracasei and 8×107 CFU Bifidobacterium longum subsp. Longum. USE - Medicine; pharmaceutics. ADVANTAGE - Invention provides higher anticancer efficacy of the immunotherapeutic regimen. 4 cl, 4 dwg, 9 tbl, 5 ex |
| IPC 分类号 | A61K-031/404 ; A61K-035/745 ; A61K-035/747 ; A61K-045/06 ; A61P-035/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19219 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | YUDIN S M,KESKINOV A A,MAKAROV V V,et al. METHOD FOR INCREASING EFFECTIVENESS OF IMMUNE CHECKPOINT INHIBITORS USING THERAPEUTIC COMPOSITION BASED ON INDOLE DERIVATIVES AND PROBIOTIC. RU2826495-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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