| METHOD OF PRODUCING NANODISPERSIONS BASED ON CONJUGATE OF ALPHA-LIPOIC ACID WITH GLUTATHIONE | |
| 2023-11-29 | |
| 专利权人 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 申请日期 | 2023-11-29 |
| 专利号 | RU2826374-C1 |
| 成果简介 | NOVELTY - Disclosed is a method of producing a nanodispersion of a conjugate of alpha-lipoic acid with glutathione (LA-GSH), involving the following steps: (a) activation of the carboxyl group of lipoic acid with N-hydroxysuccinimide in presence of 1,3-dicyclohexylcarbodiimide in dry tetrahydrofuran to obtain an N-hydroxysuccinimide ester of lipoic acid; (b) blocking the mercapto group of glutathione by trityl protection to obtain S-tritylglutathione; (c) conjugating N-hydroxysuccinimide ester of lipoic acid obtained in step (a) with S-tritylglutathione obtained in step (b), in methylene chloride with the activating action of triethylamine to obtain a reaction product of N-lipoyl-S-trityl-glutathione; (d) acid hydrolysis of the reaction product obtained in step (c), with extraction of the LA-GSH conjugate; (e) dispersing the LA-GSH conjugate in an aqueous solution of Pluronic F68 with intense stirring to form a nanodispersion of the LA-GSH conjugate. USE - Pharmaceutical industry. ADVANTAGE - Invention provides the development of a technology for producing nanodispersions of a conjugate of α-lipoic acid and glutathione, with output of all synthesis steps in range of 44–72% with increased colloidal stability, antioxidant and antiaggregation efficiency. 6 cl, 5 dwg, 1 tbl, 2 ex |
| IPC 分类号 | A61K-031/385 ; A61K-038/06 ; A61K-009/10 ; A61P-039/06 ; A61P-007/02 ; B01J-013/00 ; B82B-001/00 ; B82B-003/00 ; B82Y-040/00 ; B82Y-005/00 ; C07B-051/00 ; C07D-339/04 ; C07K-005/083 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19142 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 推荐引用方式 GB/T 7714 | INSHAKOVA A M,SHCHELKONOGOV V A,CHEKANOV A V,et al. METHOD OF PRODUCING NANODISPERSIONS BASED ON CONJUGATE OF ALPHA-LIPOIC ACID WITH GLUTATHIONE. RU2826374-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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