| METHOD OF PRODUCING CLADRIBINE BY ENZYMATIC TRANSGLYCOSYLATION OF 2-CHLORO-6-AZIDOPURINE WITH SUCCESSIVE TWO-STEP CONVERSION OF AZIDO GROUP | |
| 2023-12-04 | |
| 专利权人 | ENGELHARDT INST MOLECULAR BIOLOGY (ENGE-Non-standard) |
| 申请日期 | 2023-12-04 |
| 专利号 | RU2836333-C1 |
| 成果简介 | NOVELTY - Invention relates to biochemistry and biotechnology. Disclosed is a method for chemical-enzymatic production of cladribine and its purification from recombinant enzyme impurities. Cladribine is obtained by enzymatic transglycosylation of 2-chloro-6-azidopurine with successive two-step conversion of the azido group, which enables to extract the target product by extraction from the aqueous phase. USE - Biotechnology; chemistry. ADVANTAGE - Invention provides an enzymatic reaction in a homogeneous medium and a high degree of purification of the end product from impurities of the recombinant enzyme. 2 cl, 6 dwg, 9 ex |
| IPC 分类号 | C07D-473/40 ; C07H-019/173 ; C12N-009/10 ; C12P-019/40 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19088 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | ENGELHARDT INST MOLECULAR BIOLOGY (ENGE-Non-standard) |
| 推荐引用方式 GB/T 7714 | ALEKSEEV K S,KUROCHKIN N N,DRENICHEV M S,et al. METHOD OF PRODUCING CLADRIBINE BY ENZYMATIC TRANSGLYCOSYLATION OF 2-CHLORO-6-AZIDOPURINE WITH SUCCESSIVE TWO-STEP CONVERSION OF AZIDO GROUP. RU2836333-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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