| HYDROXAMIC ACIDS CONTAINING 1,2,4- AND 1,3,4-OXADIAZOLE NUCLEI AS POTENTIATORS OF ANTIBIOTIC ACTION | |
| 2023-12-08 | |
| 专利权人 | UNIV SIRIUS SCI & TECHNOLOGICAL (UYSI-Non-standard) |
| 申请日期 | 2023-12-08 |
| 专利号 | RU2830361-C1 |
| 成果简介 | NOVELTY - Invention relates to uridine diphosphate-3-O-(hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) enzyme inhibitors of formula (I) where A is 3,5-disubstituted nucleus of 1,2,4-oxadiazole (in the form of two regioisomers 1 and 2) or 2,5-disubstituted nucleus of 1,3,4-oxadiazole 3: B is a functional group of hydroxamic acid (C(O)NHOH), free or conjugated with an aliphatic or aromatic linker: R1 is H, F, H3CO, H3C; R2 is H, F, C1, I, H3CO, H3C; R3 is H, F, C1, I, H3CO, F3CO; R4 is H, F; R5 is H, F. USE - Chemistry. ADVANTAGE - Synthesis of new chemical compounds, which are inhibitors of the LpxC enzyme, having pharmacological activity, a decrease in the cytotoxicity of the synthesized chemical compounds, which are inhibitors of the LpxC enzyme, improvement of ADME-properties of synthesized chemical compounds, which are inhibitors of LpxC enzyme, is shown. 35 cl, 11 tbl, 99 ex, 13 dwg |
| IPC 分类号 | A61K-031/4245 ; A61P-031/04 ; C07D-271/06 ; C07D-271/10 ; C07D-271/107 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/19017 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV SIRIUS SCI & TECHNOLOGICAL (UYSI-Non-standard) |
| 推荐引用方式 GB/T 7714 | CHERNYSHOV V V,ZHUKOVETS A A,ALMUKHAMETOV A Z,et al. HYDROXAMIC ACIDS CONTAINING 1,2,4- AND 1,3,4-OXADIAZOLE NUCLEI AS POTENTIATORS OF ANTIBIOTIC ACTION. RU2830361-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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