METHOD FOR MODELLING FUNGAL KERATITIS IN RABBITS
	GANIATULLINA D R; SAMOYLOV A N; LISOVSKAYA S A
	2023-12-18
专利权人	UNIV KAZAN MED STATE (UYKZ-Non-standard)
申请日期	2023-12-18
专利号	RU2823978-C1
成果简介	NOVELTY - Invention refers to medicine, namely to experimental ophthalmology. During the first days in the conjunctival cavity and surface of the cornea, 5% Formalinan alcohol solution is instilled 5 times. Next day, 0.1% Dexamethasone is instilled 5 times day for 3 days. On 4th day, 2-3 drops of 99% Dimexidum concentrate are instilled and the cornea and conjunctival cavity are washed with 0.1% Dexamethasone solution. After washing under local anaesthesia with 0.4% Oxybuprocaine, corneal epithelium measuring 10×10 mm is scarified with a sterile microsurgical blade pre-wetted in 106 CFU/ml clinical suspension of fungal isolates of Candida spp., including fragments of mycelium. After scarification, conjunctival surface is irrigated with 106 CFU/ml clinical suspension of fungal isolates of Candida spp., and 0.2-0.3 ml of the same suspension is applied on inner surface of soft contact lens. Soft contact lens is put on the cornea and on the following days after 1 day for 5-6 approaches, additional irrigation of the cornea is performed by moving the soft contact lens, with 99% Dimexidum concentrate, clinical suspension of fungal isolates of Candida spp. 106 CFU/ml. On 10-11th day, fungal keratitis is obtained. USE - Medicine. ADVANTAGE - Method enables to reproduce an experimental model of fungal keratitis caused by a clinical suspension of Candida species in rabbits in a low-traumatic, reliable and easy manner, which, in turn, enables to expand the possibilities for studying the pathological process and developing local etiotropic treatment. 1 cl, 3 dwg, 1 ex
IPC 分类号	A61B-017/00 ; A61B-017/3211 ; A61K-031/115 ; A61K-031/245 ; A61K-031/573 ; A61K-036/06 ; A61K-047/20 ; A61P-023/02 ; A61P-043/00 ; G09B-023/28
国家	俄罗斯
专业领域	农业科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/18891
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV KAZAN MED STATE (UYKZ-Non-standard)
推荐引用方式 GB/T 7714	GANIATULLINA D R,SAMOYLOV A N,LISOVSKAYA S A. METHOD FOR MODELLING FUNGAL KERATITIS IN RABBITS. RU2823978-C1[P]. 2023.

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