Composite for three-dimensional (3D) printing of tissue scaffolds comprises shape memory polymer; and photothermal nano filler, where shape memory polymer comprises poly(L-lactide-cotrimethylene carbonate) and the photothermal nano filler is polydopamine nanoparticles, gold nanoparticles, etc
	CHATTERJEE K; JOSHI A; CHOUDHURY S
	2023-12-19
专利权人	INDIAN INST SCI (INDF-C)
申请日期	2023-12-19
专利号	IN202341086960-A
成果简介	NOVELTY - Composite comprises (i) a shape memory polymer; and (ii) a photothermal nanofiller, where the shape memory polymer comprises poly(L-lactide-cotrimethylene carbonate) (PLMC); and the photothermal nano filler is polydopamine nanoparticles (PDANPs), gold nanoparticles, carbon nanotubes, graphene oxide, or its mixtures. USE - composite for three-dimensional (3D) printing of tissue scaffolds. ADVANTAGE - The composites were printed into a variety of shapes, including tissue scaffolds that were shown to exhibit excellent shape recoveries ( > 99%), within a minute. The 3D printed composite scaffolds exhibited shape recovery from a deformed temporary shape to their original shapes intraoperatively in rabbit cranial defect models. The PLMC-PDANPs 3D printed composite scaffolds also exhibited bioactivity, in terms of higher osteogenic potential in vitro, when compared with neat PLMC, through ALP (alkaline phosphatase) activity and ARS (alizarin red staining) assays and in vivo bone regeneration through micro-CT and immune histochemical analysis. The NIR-triggered 3D printed composite scaffolds have potential for use in implantable applications, where they can be deployed remotely using a benign stimulus that can be precisely controlled and guided at physiological temperatures.The NIR-triggered 3D printed composite scaffolds have potential for use in implantable applications, where they can be deployed remotely using a benign stimulus that can be precisely controlled and guided at physiological temperatures. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: a preparation method of the composite involves mixing the photothermal nano filler selected from polydopamine nanoparticles (PDANPs), gold nanoparticles, carbon nanotubes, graphene oxide, or mixtures thereof, in a solvent to obtain a first mixture; and 5 ii) contacting the first mixture with a solution comprising the shape memory polymer and a solvent, wherein the shape memory polymer comprises poly(L-lactide-co-trimethylene carbonate) (PLMC), and preferably casting in a mold, to obtain the composite; a 3D printed composite scaffold; a method of fabricating the 3D printed composite scaffold; a product comprising the 3D printed composite scaffold; a method of treating a target site in a subject, involves providing the 3D printed composite scaffold to the target site in the subject; where the scaffold is capable of self-fitting to the 15 target site on exposure to NIR irradiation; and a method of eliminating defective cells in a subject, comprising providing the 3D printed composite scaffold.
IPC 分类号	B22F-010/20 ; B23P-023/04 ; B33Y-030/00 ; G03B-027/73 ; G03F-007/20
国家	印度
专业领域	材料科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/18865
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST SCI (INDF-C)
推荐引用方式 GB/T 7714	CHATTERJEE K,JOSHI A,CHOUDHURY S. Composite for three-dimensional (3D) printing of tissue scaffolds comprises shape memory polymer; and photothermal nano filler, where shape memory polymer comprises poly(L-lactide-cotrimethylene carbonate) and the photothermal nano filler is polydopamine nanoparticles, gold nanoparticles, etc. IN202341086960-A[P]. 2023.

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