| AGENT OF HUMIC NATURE, WHICH ENHANCES PHAGOCYTIC ACTIVITY OF CELLS | |
| 2023-12-25 | |
| 专利权人 | AS RUSSIA TOMSK NAT RES MEDICAL CENT (ASTO-Non-standard) |
| 申请日期 | 2023-12-25 |
| 专利号 | RU2834961-C1 |
| 成果简介 | NOVELTY - Invention relates to medicine, specifically to pharmacology, the results of which can be used to activate cell phagocytosis and enhance non-specific resistance of macrophages before interaction with other immune cells of the body when correcting a pathological state of the immune system associated with a deficiency in the development of a Th1-dependent immune response in chronic and recurrent infectious diseases. Proposed is the use of water-soluble humic acids from peat of an oligotrophic bog, obtained by preliminary drying, grinding, sieving through a sieve of raw materials, further treatment with 0.1 M sodium pyrophosphate solution in a weight ratio of 1:100 with constant stirring for 8 hours, separation on a vacuum nutsche filter, dissolving obtained extract with hydrochloric acid pH=1-2, precipitation by centrifugation, washing precipitate with purified water pH=7 and drying at room temperature, with weight-average molecular weight 39698.0 Da, number-average molecular weight 7737.8 Da, median 17526.4 Da and polydispersity 5.1; with weight-average molecular weight of 22783.9 Da, number-average molecular weight of 6110.2 Da, median 11798.9 Da and polydispersity 3.7; and with weight-average molecular weight 18755.3 Da, number-average molecular weight 4871.2 Da, median 9558.3 Da and polydispersity 3.9 as an agent enhancing phagocytic activity of cells. USE - Medicine. ADVANTAGE - Application described above extends the range of non-toxic immunostimulating agents of natural origin, having a pronounced ability to enhance phagocytic properties of macrophages and neutrophils, increasing both the number of phagocytes and the intensity of particle absorption. 1 cl, 4 tbl, 2 ex |
| IPC 分类号 | A61K-035/10 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/18746 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | AS RUSSIA TOMSK NAT RES MEDICAL CENT (ASTO-Non-standard) |
| 推荐引用方式 GB/T 7714 | DANILETS M G,ZYKOVA M V,TROFIMOVA E S,et al. AGENT OF HUMIC NATURE, WHICH ENHANCES PHAGOCYTIC ACTIVITY OF CELLS. RU2834961-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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