| BIOMOLECULAR COMPLEXES FOR BINDING WITH DNA MOLECULES BASED ON CAS-PROTEINS AND CHIMERIC RNA SEQUENCES CONTAINING DIMERISABLE RNA SEQUENCES | |
| 2023-12-30 | |
| 专利权人 | UNIV MOSC LOMONOSOV (MOSU-C) |
| 申请日期 | 2023-12-30 |
| 专利号 | RU2835928-C1 |
| 成果简介 | NOVELTY - Present invention relates to the field of biotechnology, in particular to systems for controlling gene expression, systems for creating synthetic genetic circuits in living cells, systems for targeted delivery of molecules to regions of the genome, genome and epigenome editing systems based on nucleotide sequence coding nCas9/dCas9 proteins, and nucleotide sequences coding RNA molecules with self-dimerizing RNA domains, as a tool for increasing the binding specificity of CRISPR/nCas9 and CRISPR/dCas9 with target DNA sequences. USE - Biotechnology. ADVANTAGE - Method for increasing the binding specificity of CRISPR/nCas9 and CRISPR/dCas9 complexes, according to the present invention, is of great importance for creating cellular biomedical products and gene therapy of human hereditary diseases. 6 cl, 7 dwg, 1 ex |
| IPC 分类号 | C07K-014/315 ; C07K-019/00 ; C12N-015/09 ; C12N-015/11 ; C12N-009/22 ; C12Q-001/68 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/18570 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV MOSC LOMONOSOV (MOSU-C) |
| 推荐引用方式 GB/T 7714 | KRISTOVSKII N V,MAMAEVA N I,KRAVCHUK E V,et al. BIOMOLECULAR COMPLEXES FOR BINDING WITH DNA MOLECULES BASED ON CAS-PROTEINS AND CHIMERIC RNA SEQUENCES CONTAINING DIMERISABLE RNA SEQUENCES. RU2835928-C1[P]. 2023. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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