Synthesis of glycoconjugates using cut-insert stitch-editing reaction involves cutting interglycosidic bond of saccharide compound in regiospecific manner using nucleophile and boron trifluoride diethyl etherate in solvent
	PASARI S; KUNDU S; SEN S; HOTHA S
	2024-02-01
专利权人	INDIAN INST SCI EDUCATION & RES (INSC-Non-standard)
申请日期	2024-02-01
专利号	IN202421006807-A
成果简介	NOVELTY - Synthesis of the glycoconjugates using a cut-insert stitch-editing reaction (CIStER) involves: (a) cutting an interglycosidic bond of saccharide compound in a regiospecific manner using nucleophile (pTolSH) and boron trifluoride diethyl etherate (BF3Et2O) in a solvent to afford thiotolyl gentiobiose and monosaccharide; (b) inserting Janus glycosyl acceptor donor compounds with thiotolyl gentiobiose in presence of reagent N-iodosuccinimide (NIS)/silver trifluoromethanesulfonate (AgOTf ) and solvent to obtain janus saccharides compound; and (c) stitching the obtained janus-saccharides compound with monosaccharide in presence of [Au]/[Ag] catalyst and solvent to obtain stitched product, glycoconjugates. USE - Method for synthesis of the glycoconjugates using a cut-insert stitch-editing reaction (CIStER). ADVANTAGE - The method is a one pot-three step chemical approach for stereo- and regio-selectively synthesize complex and branched glycoconjugates.
IPC 分类号	C07H-001/00 ; C07H-001/06 ; C07H-015/18
国家	印度
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/18275
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST SCI EDUCATION & RES (INSC-Non-standard)
推荐引用方式 GB/T 7714	PASARI S,KUNDU S,SEN S,et al. Synthesis of glycoconjugates using cut-insert stitch-editing reaction involves cutting interglycosidic bond of saccharide compound in regiospecific manner using nucleophile and boron trifluoride diethyl etherate in solvent. IN202421006807-A[P]. 2024.

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