METHOD FOR PREDICTION OF RESPONSE TO FIRST-LINE POLYCHEMOTHERAPY ACCORDING TO THE BEACOPP-14 SCHEME OF PATIENTS WITH NODULAR SCLEROSIS OF CLASSICAL HODGKIN'S LYMPHOMA BY MORPHOMETRIC ASSESSMENT OF RELATIVE CONTENT OF CD20, CD4 AND CD8-POSITIVE CELLS OF THE MICROENVELOPMENT
	DYAKONOV D A; MINAEV M S; ZHIZHINA O G; GLUBOKOVSKIKH N V
	2024-03-07
专利权人	KIROV RES INST HEMATOLOGY & BLOOD TRANSF (KIRO-Soviet Institute)
申请日期	2024-03-07
专利号	RU2835357-C1
成果简介	NOVELTY - Invention refers to medicine, namely to haematology, and can be used for prediction of response to first-line polychemotherapy according to the scheme BEACOPP-14 of patients with nodular sclerosis of classical Hodgkin's lymphoma. In the histological sections of the lymph nodes, the average relative content of CD20, CD4 and CD8-positive cells is calculated after immunohistochemical staining of the lymph nodes, followed by the calculation of a percentage index (PI) of the above microenvelopment cells. If the PI is more than or equal to 0.9, a complete response to the first-line polychemotherapy according to the BEACOPP-14 scheme is predicted. If the PI value is less than 0.9, the insufficient or partial response to the first-line polychemotherapy according to the BEACOPP-14 regimen or the absence thereof is predicted. USE - Medicine. ADVANTAGE - Method enables predicting the response to the first-line therapy of the patients with nodular sclerosis of classical Hodgkin's lymphoma by morphometric assessment of the relative content of CD20, CD4 and CD8-positive cells of the microenvelopment with calculation of their PI. 1 cl, 2 ex
IPC 分类号	G01N-001/30 ; G01N-033/483 ; G01N-033/68
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/17828
专题	中国科学院新疆生态与地理研究所
作者单位	KIROV RES INST HEMATOLOGY & BLOOD TRANSF (KIRO-Soviet Institute)
推荐引用方式 GB/T 7714	DYAKONOV D A,MINAEV M S,ZHIZHINA O G,et al. METHOD FOR PREDICTION OF RESPONSE TO FIRST-LINE POLYCHEMOTHERAPY ACCORDING TO THE BEACOPP-14 SCHEME OF PATIENTS WITH NODULAR SCLEROSIS OF CLASSICAL HODGKIN'S LYMPHOMA BY MORPHOMETRIC ASSESSMENT OF RELATIVE CONTENT OF CD20, CD4 AND CD8-POSITIVE CELLS OF THE MICROENVELOPMENT. RU2835357-C1[P]. 2024.

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