| METHOD FOR NON-INVASIVE DIAGNOSIS OF ENDOMETRIOSIS BY LIPID PROFILE OF DRY DROPS OF MENSTRUAL BLOOD | |
| 2024-03-07 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2024-03-07 |
| 专利号 | RU2829265-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to gynaecology, and can be used for diagnosing endometriosis. Samples of patient’s menstrual blood are obtained, lipid extract of dry drops of menstrual blood is prepared, lipid profile of dry menstrual blood spots is obtained by high-performance liquid chromatography with mass spectrometry (HPLC-MS). Based on lipids PE P-16:0/18:1 and PE P-18:0/20:4, calculated is a response variable y': where I PE P-16:0/18:1 _ area of peaks of lipid marker of plasmenyl-phosphatyl ethanolamine PE P-16:0/18:1 on a chromatogram of a sample of a lipid extract of a dry spot of menstrual blood of a patient, standard units; I PE P-18:0/20:4 _ area of peaks of the lipid marker of plasmenyl-phosphatyl ethanolamine PE P-18:0/20:4 on a chromatogram of a sample of a lipid extract of a dry spot of menstrual blood of a patient, standard units. At value y' from 0.68 to 1, endometriosis is diagnosed in the patient. At value y' from 0 to 0.68, the absence of endometriosis is diagnosed in the patient. USE - Medicine. ADVANTAGE - Method enables early non-invasive diagnosis of endometriosis of various severity by analysing the lipid profile of dry drops of menstrual blood by HPLC-MS as a result of applying a classifying model built on the basis of a logistic regression method for calculating a response variable (y'): taking into account levels of 2 lipids: PE P-16:0/18:1 and PE P-18:0/20:4. 1 cl, 7 dwg, 4 ex |
| IPC 分类号 | G01N-030/72 ; G01N-033/49 ; G01N-033/92 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17814 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | STARODUBTSEVA N L,CHAGOVETS V V,FRANKEVICH V E,et al. METHOD FOR NON-INVASIVE DIAGNOSIS OF ENDOMETRIOSIS BY LIPID PROFILE OF DRY DROPS OF MENSTRUAL BLOOD. RU2829265-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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