Device for separating particles from sample, comprises inlet for introducing sample, microchannel for receiving sample to form fluid stream, and outlets for receiving separated particles from microchannel, where microchannel has specified height-to-width aspect ratio, and radius of curvature
	ASHWIN A; ACHARYA S; PAUL D
	2024-03-08
专利权人	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
申请日期	2024-03-08
专利号	IN202421016839-A
成果简介	NOVELTY - A device comprises at least one inlet for introducing the sample, microchannel for receiving the sample to form a fluid stream, and outlets for receiving separated sample particles from the microchannel, where the microchannel comprises a height-to-width aspect ratio (H/W) of 1-5, and radius of curvature (R) of 1-20 mm. The total flow rate of the fluid stream, the radius of curvature (R), and height-to-width aspect ratio (H/W) are configured for size-based separation of sample particles. USE - Device for separating particles such as extracellular vesicles from sample (claimed). ADVANTAGE - The device ensures rapid and label-free isolation of extracellular vesicles of ~15 minutes without mechanical damage to vesicles by preserving their functionality for downstream applications in diagnostics and therapeutics, high purity and repeatability, and the method of separation works with a small sample volume without the requirement of manual intervention or pre-processing. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for separating particles from a sample using the device, which comprises: (i) introducing a sample into the microchannel to form a fluid stream via at least one inlet; (ii) passing the fluid stream through the microchannel; (iii) separating the sample particles based on the size; and (iv) collecting separated particles through outlets.
IPC 分类号	C12M-001/00 ; C12M-003/00 ; G01N-015/10
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/17810
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
推荐引用方式 GB/T 7714	ASHWIN A,ACHARYA S,PAUL D. Device for separating particles from sample, comprises inlet for introducing sample, microchannel for receiving sample to form fluid stream, and outlets for receiving separated particles from microchannel, where microchannel has specified height-to-width aspect ratio, and radius of curvature. IN202421016839-A[P]. 2024.

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