DIAGNOSTIC TECHNIQUE FOR HEPATIC STEATOSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C
	LIOZNOV D A; TOKIN I I; TSVETKOV V; NIKITINA O E
	2024-03-12
专利权人	SCI-RES INST INFLUENZA (SCRE-Non-standard)
申请日期	2024-03-12
专利号	RU2830504-C1
成果简介	NOVELTY - Invention relates to infectious diseases, gastroenterology and hepatology, and can be used for diagnosing hepatic steatosis in patients with chronic viral hepatitis C. Patient's age, height, body mass index (BMI), and serum aspartate aminotransferase (AST) levels are determined using biochemical analysis, hepatitis C virus genotype by molecular-genetic analysis, determination of liver and pancreas size by ultrasonic examination of abdominal cavity organs. Indicators are evaluated on a binary scale: 1 or 0. Final index S is calculated by the formula: S = (min(age, BMI, P comb.) + min(age, AST, P comb.) + min(genotype, age, BMI, AST) + min(genotype, age, 1—AST, LLT/OVS) + min(genotype, age, AST, 1—LLT/OVS) + min(genotype, height, 1—BMI, AST) + min(genotype, height, AST, P comb.) + min(age, height, BMI, AST) + min(1—height, BMI, LLT/OVS, P comb.) + min(1—genotype, 1—age, height, BMI, 1—P comb.) + min(1—genotype, 1—age, BMI, AST, 1—P comb.) + min(1—genotype, 1—BMI, AST, LLT/OVS, P comb.) + min(genotype, 1—age, 1—height, 1—BMI, 1—AST, P comb.))—(min(genotype, BMI, 1—AST) + min(genotype, 1—age, BMI, 1—P comb.) + min(genotype, age, 1—AST, 1—LLT/OVS) + min(genotype, 1—height, 1—AST, 1—P comb.) + min(age, 1—height, 1—AST, 1—LLT/OVS) + min(age, 1—height, 1—AST, 1— P comb.) + min(1—genotype, 1—age, 1—height, LLT/OVS, 1—P comb.) + min(1—genotype, 1—age, 1—BMI, 1—AST, 1—P comb.) + min(1—genotype, age, height, 1—BMI, LLT/OVS) + min(1—genotype, height, 1—BMI, 1—LLT/OVS, P comb.) + min(1—genotype, age, 1—height, 1—BMI, 1—LLT/OVS, 1—P comb.)) + min(genotype, age, 1—height, 1—BMI, LLT/OVS, 1—P comb.)), where min(index 1, index 2, index 3, etc.) is the minimum value of the binary index values presented in brackets; genotype—genotype of hepatitis C virus: equal to 1 in presence of 3 genotype of hepatitis C virus, equal to 0 in absence of 3 genotype of hepatitis C virus; age: equal to 1, if the patient is more than 33.6 years old; is equal to 0 if the patient's age is less than or equal to 33.6 years; height: for males is equal to 1, if the patient's height is more than 177 cm; is equal to 0 if the patient's height is less than or equal to 177 cm; for women is equal to 1, if the patient is more than 165 cm, is equal to 0, if the patient is less than or equal to 165 cm; BMI: equal to 1, if the patient’s BMI is more than 26.4 kg/m2; is equal to 0, if the patient’s BMI is less than or equal to 26.4 kg/m2; AST: equal to 1, if the level of AST in blood serum is 1.38 times more than the upper limit of normal; otherwise equal to 0; LLT/OVS is the ratio of the of the left lobe thickness of the liver to the oblique vertical size of the liver: equal to 1, if more than 0.6463; equal to 0 if less than or equal to 0.6463; P comb.—product of partial thickness of tail to thickness of head of pancreas by thickness of pancreas body: equal to 1, if more than 18.18; is equal to 0 if less than or equal to 18.18. If the total value S is more than 0, hepatic steatosis is diagnosed in patients with chronic viral hepatitis C. USE - Medicine. ADVANTAGE - Method enables diagnosing hepatic steatosis in patients with chronic viral hepatitis C due to the routine clinical examination of the patient, the use of routine biomedical indicators and the use of the declared mathematical model, which is an interpreted algorithm—a machine learning model. 1 cl, 2 dwg, 2 tbl, 2 ex
IPC 分类号	A61B-005/107 ; A61B-008/00 ; C12Q-001/68 ; G01N-033/576 ; G01N-033/68
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/17759
专题	中国科学院新疆生态与地理研究所
作者单位	SCI-RES INST INFLUENZA (SCRE-Non-standard)
推荐引用方式 GB/T 7714	LIOZNOV D A,TOKIN I I,TSVETKOV V,et al. DIAGNOSTIC TECHNIQUE FOR HEPATIC STEATOSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C. RU2830504-C1[P]. 2024.

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