| CHIMERIC IMMUNOTOXIN BASED ON NON-STRUCTURAL GLYCOPROTEIN NSP4 OF HUMAN ROTAVIRUS, SHOWING INCREASED CYTOTOXIC EFFECT ON TUMOUR-ASSOCIATED MUC1 OF CANCER CELLS | |
| 2024-03-19 | |
| 专利权人 | NIZHNY NOVGOROD EPIDEMIOLOGY & MICROBIOL (NIZH-Non-standard) |
| 申请日期 | 2024-03-19 |
| 专利号 | RU2837117-C1 |
| 成果简介 | NOVELTY - Invention relates to biotechnology, molecular immunology and medicine. What is presented is a chimeric immunotoxin based on the non-structural glycoprotein NSP4 of human rotavirus, which exhibits an increased cytotoxic effect on the tumour-associated MUC1 of cancer cells. Immunotoxin contains a single-chain antibody binding tumour-associated MUC1, and a peptide consisting of amino acids 112-174 of non-structural glycoprotein NSP4 of human rotavirus, connected by a peptide linker. Chimeric immunotoxin initiates cell cycle arrest and cancer cell apoptosis, which provides cytotoxic activity in lower concentrations. USE - Biotechnology; medicine. ADVANTAGE - Invention can find further application in developing monitoring and therapeutic approaches in treating patients with malignant neoplasms. 1 cl, 5 dwg, 6 ex |
| IPC 分类号 | A61K-039/00 ; C07K-014/14 ; C07K-016/30 ; C07K-019/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17639 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | NIZHNY NOVGOROD EPIDEMIOLOGY & MICROBIOL (NIZH-Non-standard) |
| 推荐引用方式 GB/T 7714 | NOVIKOV D V,NOVIKOVA N A,NOVIKOV V V. CHIMERIC IMMUNOTOXIN BASED ON NON-STRUCTURAL GLYCOPROTEIN NSP4 OF HUMAN ROTAVIRUS, SHOWING INCREASED CYTOTOXIC EFFECT ON TUMOUR-ASSOCIATED MUC1 OF CANCER CELLS. RU2837117-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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