METHOD OF PRODUCING SUBSTITUTED 3-ARYLPYRROLES
	SUKHORUKOV A YU; POSPELOV E V; ZHIROV A V
	2024-03-20
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2024-03-20
专利号	RU2831117-C1
成果简介	NOVELTY - Invention relates to a method of producing substituted 3-arylpyrroles of general formula: where Ar = 6-member aryl or 5-member heteroaryl containing a heteroatom selected from S, O; R1 = lower alkyl, 6-membered aryl or CH2CH2CO2Alk, where Alk = lower alkyl; R2 = H, lower alkyl, 6-member aryl; R3 = H, CO2Alk, where Alk = lower alkyl; or R2+R3 = -(CH2)n-, where n = 4-10, consisting in the fact that corresponding aryl-substituted nitroalkenes of general formula: where R1 and Ar have the above values, are treated with enol esters of general formula: where R2 and R3 have the above values, and R4 = lower alkyl or SiAlk3, where Alk = lower alkyl, in the presence of a Lewis acid at a temperature of -70 °C to -100 °C in an aprotic solvent medium, obtained 5,6-dihydro-4H-1,2-oxazine N-oxides of general formula: where Ar, R1, R2, R3 and R4 have the above values, are treated with a metal reducing agent, such as Raney nickel, at temperature of 70-90 °C in a medium of a protic solvent, followed by extraction of the desired product. USE - Chemistry. ADVANTAGE - Design of an efficient and universal method of producing substituted 3-arylpyrroles I of general formula I with high output, which simplifies the technology of producing products I by reducing the number of steps. 4 cl, 18 ex
IPC 分类号	A61K-031/40 ; C07D-207/33 ; C07D-265/02
国家	俄罗斯
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/17611
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	SUKHORUKOV A YU,POSPELOV E V,ZHIROV A V. METHOD OF PRODUCING SUBSTITUTED 3-ARYLPYRROLES. RU2831117-C1[P]. 2024.

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