| METHOD FOR PREDICTION OF OUTCOME IN PATIENTS WITH GASTRIC CANCER AFTER COMBINED TREATMENT, INCLUDING NEOADJUVANT CHEMOTHERAPY ACCORDING TO FOLFOX6 OR FLOT REGIMENS AND SURGICAL TREATMENT | |
| 2024-03-25 | |
| 专利权人 | SUPERHARD & NEW CARBON MATERIALS INST (SUPE-Non-standard) |
| 申请日期 | 2024-03-25 |
| 专利号 | RU2831907-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to oncology, and can be used for prediction of outcome in patients with gastric cancer after combined treatment including neoadjuvant chemotherapy according to FOLFOX6 or FLOT regimens and surgical treatment. Tumour tissue is used to obtain cDNA on a total RNA matrix using a reverse transcription reaction. PD-L1 and PDK1 genes are amplified. PD-L1 and PDK1 gene expression is assessed by method 2-ΔΔCt relative to GAPDH gene. Obtained values are substituted into the regression function formula and the probability of a favourable outcome P is calculated. If P<0.061, a favourable outcome is predicted. If P>0.061, an unfavourable outcome is predicted. USE - Medicine. ADVANTAGE - Method provides more accurate and informative prediction of the outcome in the patients with gastric cancer following the combined treatment including neoadjuvant chemotherapy according to the FOLFOX6 or FLOT regimens and surgical treatment by assessing the expression of PD-L1 and PDK1 genes in the tumour tissue. 1 cl, 6 dwg, 2 ex |
| IPC 分类号 | C12Q-001/6804 ; C12Q-001/6844 ; C12Q-001/6876 ; C12Q-001/6886 ; G01N-033/50 ; G01N-033/574 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17558 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | SUPERHARD & NEW CARBON MATERIALS INST (SUPE-Non-standard) |
| 推荐引用方式 GB/T 7714 | SPIRINA L V,AVGUSTINOVICH A V,AFANASYEV S G,et al. METHOD FOR PREDICTION OF OUTCOME IN PATIENTS WITH GASTRIC CANCER AFTER COMBINED TREATMENT, INCLUDING NEOADJUVANT CHEMOTHERAPY ACCORDING TO FOLFOX6 OR FLOT REGIMENS AND SURGICAL TREATMENT. RU2831907-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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