| METHOD FOR MONITORING SERUM CONCENTRATIONS OF BEDAQUILINE FOR ASSESSING EFFECTIVENESS OF ANTI-TUBERCULOSIS CHEMOTHERAPY | |
| 2024-03-30 | |
| 专利权人 | CENT RES INST TUBERCULOSIS (RETU-Non-standard) |
| 申请日期 | 2024-03-30 |
| 专利号 | RU2831888-C1 |
| 成果简介 | NOVELTY - Invention relates to medicine, namely to pulmonology, and can be used for monitoring serum concentrations of Bedaquiline for assessing the effectiveness of anti-tuberculosis chemotherapy. Anti-tuberculosis chemotherapy is carried out in the amount of: Bedaquiline 0.4 mg once day for 14 days, then 0.2 mg 3 times a week, Linezolid 0.6 mg once a day, Moxifloxacin 0.4 mg once a day, Cycloserine 0.25 mg 3 times a day, Pyrazinamide 0.5 mg 3 times a day, Amikacin 1.0 g once a day. Blood is sampled for a pharmacokinetic study, which includes three procedures, in the first of which blood is sampled on the day of the beginning of Bedaquiline intake at six time points at 8:00, 11:00, 14:00, 17:00, 21:00, 21:00, in the second, blood is sampled on the fourteenth day from the day of taking Bedaquiline at five time points at 8:00, 14:00, 17:00, 19:00, 21:00, in the third, blood is sampled on the eighty-fourth day from the day of the beginning of Bedaquiline intake at five time points at 8:00, 14:00, 17:00, 19:00, 21:00. During each blood sampling after taking into a test tube, it is smoothly turned 6 times for blood mixing, placed in rack for 45 minutes in an upright position at room temperature, centrifugation is carried out for 10 minutes at 3,000 rpm, the test tube is placed in a vertical position and placed in a refrigerator for use. Concentration of Bedaquiline in the sample is determined in mcg/l. If the serum concentration of Bedaquiline is more than or equal to 0.84 mcg/l, the anti-tuberculosis chemotherapy is considered to be effective. USE - Medicine. ADVANTAGE - Method provides the possibility of increasing the accuracy of assessing the effectiveness of antituberculous chemotherapy by determining the dynamics of serum concentrations of Bedaquiline in order to ensure correction of the dose of Bedaquiline for the entire period of patient's treatment. 1 cl, 4 dwg, 2 ex |
| IPC 分类号 | A61K-031/00 ; A61K-031/47 ; A61P-031/06 ; G01N-001/28 ; G01N-033/49 ; G01N-033/94 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17449 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | CENT RES INST TUBERCULOSIS (RETU-Non-standard) |
| 推荐引用方式 GB/T 7714 | CHUMOVATOV N V,CHERNYKH N A,ZAKHAROV A V,et al. METHOD FOR MONITORING SERUM CONCENTRATIONS OF BEDAQUILINE FOR ASSESSING EFFECTIVENESS OF ANTI-TUBERCULOSIS CHEMOTHERAPY. RU2831888-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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