| 5-AMINO-3-(MORPHOLINE-4-CARBONYL)-1-(2-OXO-2-(4-FLUOROPHENYL)ETHYLIDENE)-6,7,8,9-TETRAHYDROBENZO(4,5)THIENO(3,2-E)PYRROLO(1,2-A)PYRIMIDIN-2(1H)-ONE, HAVING ANTI-INFLAMMATORY ACTIVITY | |
| 2024-04-04 | |
| 专利权人 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 申请日期 | 2024-04-04 |
| 专利号 | RU2831363-C1 |
| 成果简介 | NOVELTY - Invention relates to organic chemistry, to novel biologically active substances of the class of substituted thienopyrrolopyrimidines. Disclosed is 5-amino-3-(morpholine-4-carbonyl)-1-(2-oxo-2-(4-fluorophenyl)ethylidene)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidine-2(1H)-one of formula: having anti-inflammatory activity. 5-amino-3-(morpholine-4-carbonyl)-1-(2-oxo-2-(4-fluorophenyl)ethylidene)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidin-2(1H)-one is obtained by interaction of nitrile of 2-((2-oxo-5-(4-fluorophenyl)furan-3(2H)-ylidene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid with 3-morpholino-3-oxopropane nitrile in presence of 1 equivalent of diisopropylethylamine (DIPEA). Reaction takes place in dioxane while stirring and temperature of 90 °C with subsequent extraction of target products using known methods. USE - Organic chemistry. ADVANTAGE - Obtaining a compound with high output, having pronounced anti-inflammatory activity, as well as low toxicity. 1 cl |
| IPC 分类号 | A61K-031/519 ; A61P-029/00 ; C07D-495/04 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17366 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 推荐引用方式 GB/T 7714 | SERGEY SH,MAKHMUDOV R R,GORBUNOVA I A,et al. 5-AMINO-3-(MORPHOLINE-4-CARBONYL)-1-(2-OXO-2-(4-FLUOROPHENYL)ETHYLIDENE)-6,7,8,9-TETRAHYDROBENZO(4,5)THIENO(3,2-E)PYRROLO(1,2-A)PYRIMIDIN-2(1H)-ONE, HAVING ANTI-INFLAMMATORY ACTIVITY. RU2831363-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论