| METHOD OF PRODUCING 2a,4-DIPHENYL-5-(4-(TRIFLUOROMETHYL)BENZOYL)-2a,3,4,5-TETRAHYDRO-1H-SPIRO(AZETO(1,2-d)BENZO(b)(1,4)DIAZEPIN-2,1'-CYCLOPROPANE)-1-ONE, EXHIBITING CYTOTOXICITY ON CELLS HEK 293 | |
| 2024-04-08 | |
| 专利权人 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 申请日期 | 2024-04-08 |
| 专利号 | RU2829460-C1 |
| 成果简介 | NOVELTY - Invention relates to organic chemistry and specifically to a method of producing 2a,4-diphenyl-5-(4-(trifluoromethyl)benzoyl)-2a,3,4,5-tetrahydro-1H-spiro[azeto[1,2-d]benzo[b][1,4]diazepin-2,1'-cyclopropane]-1-one of formula 1. Method involves reaction of 2,4-diphenyl-1-(4-trifluoromethyl)benzoyl-2,3-dihydro-1H-1,5-benzodiazepine of formula 2 with methyl ester of 1-bromocyclopropane carboxylic acid and zinc in o-xylene medium at boiling for 6 hours with subsequent treatment of reaction mass and extraction of target products. USE - Chemistry. ADVANTAGE - Method enables to obtain 2a,4-diphenyl-5-(4-(trifluoromethyl)benzoyl)-2a,3,4,5-tetrahydro-1H-spiro[azeto[1,2-d]benzo[b][1,4]diazepin-2,1'-cyclopropan]-1-one, having cytotoxic activity. 1 cl, 1 tbl, 2 ex |
| IPC 分类号 | C07D-487/04 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17321 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C) |
| 推荐引用方式 GB/T 7714 | NIKIFOROVA E A,ZVEREV D P. METHOD OF PRODUCING 2a,4-DIPHENYL-5-(4-(TRIFLUOROMETHYL)BENZOYL)-2a,3,4,5-TETRAHYDRO-1H-SPIRO(AZETO(1,2-d)BENZO(b)(1,4)DIAZEPIN-2,1'-CYCLOPROPANE)-1-ONE, EXHIBITING CYTOTOXICITY ON CELLS HEK 293. RU2829460-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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