| METHOD OF TREATING PATIENTS WITH MULTIPLE MYELOMA COMPLICATED BY DOUBLE REFRACTORINESS WITH HELP OF NATURAL KILLER-CELL ADAPTIVE IMMUNOTHERAPY | |
| 2024-04-18 | |
| 专利权人 | UNIV SAMARA MEDICAL (USMR-C) |
| 申请日期 | 2024-04-18 |
| 专利号 | RU2836995-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to haematology, and can be used in treating patients with multiple myeloma complicated by double refractoriness. Method involves weekly intravenous transfusion of donor concentrate of haematopoietic stem cells (HSC) from umbilical blood containing natural killer cells, alloreactive on KIR-receptors of receptor-ligand type (NK-cells). Umbilical blood HSC transfusion is performed once with a fixed dose of leukocytes 40.0-60.0 × 108 and NK-cells 4.0-6.0 × 108 and three times with a fixed dose of leukocytes 20.0-30.0 × 108 and NK-cells 1.4-3.0 × 108. Transfusion is preceded by a lymphodepleting chemotherapy based on cyclophosphamide in dose of 5 mg/kg; each transfusion is accompanied by the subcutaneous introduction of IL-2 in dose of 1 million units a day in amount of 5 such injections. USE - Medicine. ADVANTAGE - Using the invention enables reducing the number of plasma cells, reducing the secretion of paraprotein IgG kappa in the patients with refractoriness with no side effects. 1 cl |
| IPC 分类号 | A61K-031/675 ; A61K-035/51 ; A61P-035/02 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/17120 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV SAMARA MEDICAL (USMR-C) |
| 推荐引用方式 GB/T 7714 | DAVYDKIN I L,GRITSENKO T A,KURTOV I V,et al. METHOD OF TREATING PATIENTS WITH MULTIPLE MYELOMA COMPLICATED BY DOUBLE REFRACTORINESS WITH HELP OF NATURAL KILLER-CELL ADAPTIVE IMMUNOTHERAPY. RU2836995-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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