| METHOD FOR PREVENTION OF CORNEAL TRANSPLANT OPACITY AND VASCULARIZATION IN ANIMALS AFTER PENETRATING KERATOPLASTY WITH UNDERLYING PREEXISTING VASCULARIZED CORNEAL LEUKOMA DUE TO EYE BURN INJURY | |
| 2024-04-25 | |
| 专利权人 | TRIFANENKOVA I G (TRIF-Individual) ; TEMNOV A A (TEMN-Individual) ; BULATOVA I D (BULA-Individual) |
| 申请日期 | 2024-04-25 |
| 专利号 | RU2828627-C1 |
| 成果简介 | NOVELTY - Invention relates to ophthalmology and is intended for prevention of opacity and vascularization of corneal graft in animals after penetrating keratoplasty with underlying preexisting vascularized corneal leukoma due to burn injury of eye. Conjunctival cavity is instilled with a solution of conditioned medium of mesenchymal stem cells (CM MSC) four times for hour every 20 minutes starting from 1 day after keratoplasty for 30 days. To obtain a solution of CM MSC, a mononuclear fraction of bone marrow proper cells is isolated, the suspension is inoculated on Petri dishes and cultured in a DMEM medium with 10% FBS in a CO2 incubator at 5% CO2 and 10% O2 with a complete replacement of the culture medium after obtaining the cell monolayer, after 3 days, the conditioned culture medium is combined with the MSC lysate. USE - Medicine. ADVANTAGE - Invention provides preservation of corneal transplant transparency, reduced risk of corneal transplant vascularization. 1 cl |
| IPC 分类号 | A61F-009/01 ; A61P-027/02 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16981 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | 1.TRIFANENKOVA I G (TRIF-Individual) 2.TEMNOV A A (TEMN-Individual) 3.BULATOVA I D (BULA-Individual) |
| 推荐引用方式 GB/T 7714 | TRIFANENKOVA I G,TEMNOV A A,BULATOVA I D,et al. METHOD FOR PREVENTION OF CORNEAL TRANSPLANT OPACITY AND VASCULARIZATION IN ANIMALS AFTER PENETRATING KERATOPLASTY WITH UNDERLYING PREEXISTING VASCULARIZED CORNEAL LEUKOMA DUE TO EYE BURN INJURY. RU2828627-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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