| RECOMBINANT PLASMID DNA pQE-60_LysSte134, PROVIDING SYNTHESIS OF RECOMBINANT PROTEIN LysSte134, BACTERIAL STRAIN ESCHERICHIA COLI - PRODUCER OF RECOMBINANT PROTEIN LysSte134 AND RECOMBINANT PROTEIN LysSte134, HAVING ANTIBACTERIAL ACTION | |
| 2024-04-26 | |
| 专利权人 | AS SIBE CHEM BIOLOGY & FUNDAMENTAL MEDIC (ASIC-Non-standard) |
| 申请日期 | 2024-04-26 |
| 专利号 | RU2829504-C1 |
| 成果简介 | NOVELTY - Disclosed is a recombinant protein endolysin LysSte134 with molecular weight of 35 kDa, having antibacterial action by lysis of cell walls and destruction of biofilms formed Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus warneri, consisting of endolysin LysSte134 and C-terminal oligopeptide GSRSHHHHHH and having size of 307 a.a.r. and the amino acid sequence SEQ ID NO: 2. Also disclosed is recombinant plasmid DNA pQE-60_LysSte134, having a nucleotide sequence SEQ ID NO: 1, providing synthesis in Escherichia coli cells of said recombinant protein endolysin LysSte134 and the Escherichia coli bacterial strain M15/pQE-60_LysSte134 – producer of said recombinant protein endolysin LysSte134, obtained by transformation of Escherichia coli M15 strain of said recombinant plasmid DNA pQE-60_LysSte134. USE - Biotechnology. ADVANTAGE - Invention provides effective synthesis of recombinant endolysin LysSte134, having hydrolytic activity with respect to cell wall peptidoglycans and destroying biofilms of representatives of the genus Staphylococcus. 3 cl, 6 dwg, 6 ex |
| IPC 分类号 | C07K-014/005 ; C12N-001/21 ; C12N-015/33 ; C12N-015/70 ; C12R-001/19 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16968 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | AS SIBE CHEM BIOLOGY & FUNDAMENTAL MEDIC (ASIC-Non-standard) |
| 推荐引用方式 GB/T 7714 | MATVEEV A L,TIKUNOVA N V,GOLOSOVA N N,et al. RECOMBINANT PLASMID DNA pQE-60_LysSte134, PROVIDING SYNTHESIS OF RECOMBINANT PROTEIN LysSte134, BACTERIAL STRAIN ESCHERICHIA COLI - PRODUCER OF RECOMBINANT PROTEIN LysSte134 AND RECOMBINANT PROTEIN LysSte134, HAVING ANTIBACTERIAL ACTION. RU2829504-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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