SPINAL CORD REPAIR NEUROIMPLANT
	ZELENOVA E D; KOVALEVA P A; KARSHIEVA S SH; SENATOV F S
	2024-05-07
专利权人	UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C)
申请日期	2024-05-07
专利号	RU2829632-C1
成果简介	NOVELTY - Group of inventions refers to medicine, namely to neurosurgery, and can be used as a neuroimplant for spinal cord recovery. Neuroimplant for regeneration of spinal nerve tissue is made in the form of a biodegradable hybrid layered structure based on a water-soluble polymer, which is polyvinyl alcohol, consisting of a first layer – a lattice structure made to replace a connective tissue layer of the spinal cord and adhesion and proliferation of cells, due to the created pores with size of 70-130 mcm, and second layer – electrospinned substrate with submicron directed fibres, layers are connected to each other by means of cohesion. Method of producing a neuroimplant involves making a layered structure by producing a first layer – a lattice structure, obtained by printing on an FDM printer, and producing a second layer – an electrospinned substrate with submicron directed fibres. Both layers are joined to each other by means of cohesion, after which the obtained laminar structure is treated in glutaraldehyde cross-linking solution at pH = 2-3 for 3 hours, washed in a buffer solution at pH = 7.5 and sterilized. USE - Medicine. ADVANTAGE - Use of inventions enables to achieve an increase in the regenerative potential and the possibility of accelerating the recovery of the spinal cord in acute injury by creating a hygroscopic two-layer structure, the structure of which contributes to fixation of the implant and directed regeneration of nerve tissue, by creating a combination of a directed submicron fibrous structure for attachment and proliferation of spinal cord cells and a mesh structure providing a fixed position of the fibrous part, as well as the fact that this polymer lattice acts as a scaffold for the dura mater of the spinal cord. 2 cl, 6 dwg
IPC 分类号	A61F-002/90 ; A61K-047/58 ; A61P-025/00
国家	俄罗斯
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/16831
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV MISIS NAT SCI & TECHNOLOGY (UMNS-C)
推荐引用方式 GB/T 7714	ZELENOVA E D,KOVALEVA P A,KARSHIEVA S SH,et al. SPINAL CORD REPAIR NEUROIMPLANT. RU2829632-C1[P]. 2024.

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