METHOD OF PRODUCING 2-(FLUOROMETHOXY)-1,1,1,3,3,3-HEXAFLUOROISOPROPANE (SEVOFLURANE)
	IGUMNOV S M; BOIKO V E
	2024-05-13
专利权人	HYDROGEN ECOPEROXIDE SCI & PRODN ASSOC (HYDR-Non-standard)
申请日期	2024-05-13
专利号	RU2830201-C1
成果简介	NOVELTY - Invention relates to organic chemistry, specifically to a method for synthesis of 2-(fluoromethoxy)-1,1,1,3,3,3-hexafluoroisopropane (sevoflurane), an inhalation anaesthetic used in medicine. Method involves obtaining sevochlorane by reacting hexafluoroisopropanol with paraform or trioxane in chlorosulphonic acid, separating sevochlorane by washing with water and subsequent rectification. Further fluorination of sevochlorane is characterized by the fact that it is reacted with KF while boiling in aqueous acetonitrile in the presence of triethylbenzylammonium chloride as a phase-transfer catalyst, and the end product is extracted directly from the reaction mixture by rectification. USE - Organic chemistry. ADVANTAGE - Providing a method of producing an end product with purity higher than 99,9% and with high output. 2 cl, 5 ex
IPC 分类号	C07C-041/22 ; C07C-043/12
国家	俄罗斯
专业领域	化学化工
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/16796
专题	中国科学院新疆生态与地理研究所
作者单位	HYDROGEN ECOPEROXIDE SCI & PRODN ASSOC (HYDR-Non-standard)
推荐引用方式 GB/T 7714	IGUMNOV S M,BOIKO V E. METHOD OF PRODUCING 2-(FLUOROMETHOXY)-1,1,1,3,3,3-HEXAFLUOROISOPROPANE (SEVOFLURANE). RU2830201-C1[P]. 2024.

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