| METHOD FOR ASSESSING EFFICACY OF DRUG "LAENNEC" ON PHARMACOLOGICAL MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE WITH IRON OVERLOAD IN EXPERIMENTAL ANIMALS | |
| 2024-05-24 | |
| 专利权人 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 申请日期 | 2024-05-24 |
| 专利号 | RU2837019-C1 |
| 成果简介 | NOVELTY - Invention relates to medicine, namely to hepatology, experimental medicine, and can be used to assess the effectiveness of the drug Laennec on a pharmacological model of non-alcoholic fatty liver disease with iron overload in experimental animals – rats. Intraperitoneal introduction of iron sulphate (II) heptahydrate (C.P.) in dose of 50 mg/kg/day, in conditions of oral excessive consumption of solid fraction of palm oil in dosage of 30 g/kg/day and fructose solution in amount of 1 g/kg/days for 12 days. Then the preparation Laennec is introduced in dose of 0.6 ml/kg of body weight per day, intramuscularly, for 4 weeks. That is followed by a biochemical and general blood test. At indicators: ferritin from 127 to 175 mcg/l, transferrin saturation with iron from 25 to 39% and iron in blood serum from 20 to 30 mcmol/l, AST from 115.3 to 222.3 U/l, ALT from 30.4 to 46.6 U/l, leukocytes from 1.9×109 to 7.7×109 cells/l, thrombocytes from 547.6×109 to 734.4x109 cells/l, total protein from 53.5 to 61.7 g/l, creatinine from 27 to 30.6 mcmol/l and GFR from 165 to 178.2 ml/min/1.73 m2, Laennec therapy is considered to be effective. USE - Medicine. ADVANTAGE - Method provides the possibility of proving the efficacy of using a standardized human placenta hydrolyzate of the drug Laennec by assessing the efficacy of Laennec on a histologically confirmed model of non-alcoholic fatty liver disease with multiple organ pathology in rats, caused by the combined intake of excess fats – palm oil, carbohydrates – fructose and inorganic iron – iron sulphate, using evidence in the form of changes in clinical, biochemical, general blood test values and histological markers. 1 cl, 21 dwg, 9 ex |
| IPC 分类号 | A61K-035/50 ; A61P-001/16 ; G01N-033/49 ; G01N-033/68 ; G01N-033/70 ; G01N-033/84 ; G01N-033/90 ; G09B-023/28 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16618 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY EDUCATIONAL (BUDG-Non-standard) |
| 推荐引用方式 GB/T 7714 | BOGACHEVA T E,GROMOVA O A,GRISHINA T R,et al. METHOD FOR ASSESSING EFFICACY OF DRUG "LAENNEC" ON PHARMACOLOGICAL MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE WITH IRON OVERLOAD IN EXPERIMENTAL ANIMALS. RU2837019-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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