| METHOD FOR DIFFERENTIAL DIAGNOSIS OF CHRONIC HEPATITIS B AND AUTOIMMUNE LIVER DISEASES IN PATIENTS WITH SEVERE FIBROSIS AND CIRRHOSIS | |
| 2024-05-28 | |
| 专利权人 | UNIV URAL FEDERAL (UYUR-C) |
| 申请日期 | 2024-05-28 |
| 专利号 | RU2834900-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to hepatology, laboratory diagnostics, and can be used for differential diagnosis of chronic hepatitis B (CHB) and autoimmune liver diseases (AILD) in patients with severe fibrosis and cirrhosis. Blood plasma is analysed for concentration of cytokines IL-2 in pg/ml, IL-8 in pg/ml, IL-18 in pg/ml. Diagnosis in a patient with severe fibrosis and cirrhosis is established by comparing the obtained values with threshold values: at the first stage, concentration of IL-18 is assessed, at the value of which is more than or equal to 200.85 pg/ml CHB is diagnosed, the value less than 200.85 pg/ml requires the second stage. At the second stage, the IL-8 concentration is assessed; if the value is less than 3.86 pg/ml, AILD is diagnosed, and the third stage is required if the value is more than or equal to 3.86 pg/ml. At the third stage, the IL-2 concentration is assessed; if the value is less than 0.137 pg/ml, CHB is diagnosed, and if the value is more than or equal to 0.14, AILD is diagnosed. USE - Medicine. ADVANTAGE - Method enables differential diagnosis of chronic hepatitis B and autoimmune liver diseases, including autoimmune hepatitis and primary biliary cirrhosis, in patients with severe fibrosis and cirrhosis (F3-4) with a high level of sensitivity and maintaining the required specificity by determining three cytokines in blood plasma: IL-2, IL-8, IL-18. 1 cl, 1 dwg, 3 ex |
| IPC 分类号 | G01N-033/573 ; G01N-033/68 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16558 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV URAL FEDERAL (UYUR-C) |
| 推荐引用方式 GB/T 7714 | BATSUNOV O K,ARSENTEVA N A,LYUBOVOVA N E,et al. METHOD FOR DIFFERENTIAL DIAGNOSIS OF CHRONIC HEPATITIS B AND AUTOIMMUNE LIVER DISEASES IN PATIENTS WITH SEVERE FIBROSIS AND CIRRHOSIS. RU2834900-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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