METHOD FOR MORPHOMETRIC ASSESSMENT OF CLINICAL COURSE OF DIFFUSE LARGE B-CELL LYMPHOMA BY FRACTION INDEX OF CD4+ AND CD8+ T-LYMPHOCYTES OF MICROENVELOPMENT IN LYMPH NODES
	VANEEVA E V; ROSIN V A; DYAKONOV D A; GLUBOKOVSKIKH N V
	2024-05-28
专利权人	KIROV RES INST HEMATOLOGY & BLOOD TRANSF (KIRO-Soviet Institute)
申请日期	2024-05-28
专利号	RU2834382-C1
成果简介	NOVELTY - Invention refers to medicine, namely to haematology, and can be used for morphometric assessment of the clinical course of diffuse large B-cell lymphoma by the fraction index of CD4+ and CD8+ T-lymphocytes of the microenvelopment in the lymph nodes. Lymphadenectomy is followed by a histological introduction of the analysed material, immunohistochemical analysis on sections of lymph nodes with antibodies to CD4- and CD8-lymphocytes of the microenvironment, and their relative number is calculated. Fraction index FICD4+/CD8+ is determined. If the FICD4+/CD8+ is less than 13.5%, the unfavourable outcome of the disease is predicted. If FI is 13.5% or more, a favourable course of diffuse large B-cell lymphoma is predicted. USE - Medicine. ADVANTAGE - Method provides the morphometric assessment of the clinical course of diffuse large B-cell lymphoma by determining the FICD4+/CD8+ in the lymph nodes. 1 cl, 3 ex
IPC 分类号	G01N-001/30 ; G01N-033/483 ; G01N-033/68
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/16529
专题	中国科学院新疆生态与地理研究所
作者单位	KIROV RES INST HEMATOLOGY & BLOOD TRANSF (KIRO-Soviet Institute)
推荐引用方式 GB/T 7714	VANEEVA E V,ROSIN V A,DYAKONOV D A,et al. METHOD FOR MORPHOMETRIC ASSESSMENT OF CLINICAL COURSE OF DIFFUSE LARGE B-CELL LYMPHOMA BY FRACTION INDEX OF CD4+ AND CD8+ T-LYMPHOCYTES OF MICROENVELOPMENT IN LYMPH NODES. RU2834382-C1[P]. 2024.

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