| SINGLE-LAYER LIPOSOMES CONTAINING MICAFUNGIN | |
| 2024-06-08 | |
| 专利权人 | AS RUSSIA CYTOLOGY INST (ASCY-Non-standard) |
| 申请日期 | 2024-06-08 |
| 专利号 | RU2835492-C1 |
| 成果简介 | NOVELTY - Invention relates to biotechnology, in particular to novel antifungal agents based on liposomes. Disclosed are single-layer liposomes containing micafungin. Additionally, liposomes can contain phloretin in equimolar ratio with lipid. Antifungal activity of the liposomes of the present invention is considerably higher than the activity of amphotericin B known from the prior art, which is confirmed by their significantly lower minimum inhibitory concentration (MIC) compared to amphotericin B. Thus, MIC of single-layer liposomes with micafungin with respect to fluconazole-resistant clinical isolates of Candida species is 8-60 times lower than MIC of amphotericin B. USE - Biotechnology. ADVANTAGE - Adding phloretin to liposomes with micafungin reduces MIC by 14 times. 4 cl, 5 dwg, 3 tbl, 2 ex |
| IPC 分类号 | A61K-038/12 ; A61K-009/127 ; A61P-031/10 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16338 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | AS RUSSIA CYTOLOGY INST (ASCY-Non-standard) |
| 推荐引用方式 GB/T 7714 | OSTROUMOVA O S,MALYKHINA A I,EFIMOVA S S,et al. SINGLE-LAYER LIPOSOMES CONTAINING MICAFUNGIN. RU2835492-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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