| SET OF RECOMBINANT GENETIC VECTORS CODING BROADLY NEUTRALIZING ANTIBODIES AGAINST HIV-1, IMMUNOBIOLOGICAL PREPARATION FOR TREATMENT AND PREVENTION OF HIV INFECTION AND METHOD OF ITS APPLICATION | |
| 2024-06-18 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2024-06-18 |
| 专利号 | RU2833072-C1 |
| 成果简介 | NOVELTY - Invention relates to biotechnology, namely to recombinant genetic vectors based on adeno-associated virus, coding broadly neutralizing antibodies against human immunodeficiency virus (HIV-1), as well as to immunobiological preparations based on them for treating and preventing HIV infection by providing long-term persistence of widely neutralizing antibodies against HIV-1. Described is a set of recombinant genetic vectors coding broadly neutralizing antibodies against HIV-1, directed to different epitopes of viral protein Env, where the recombinant genetic vector used is an adeno-associated vector of serotype 9. What is presented is an immunobiological preparation for treating or preventing HIV-1 infection, containing a combination of several serotype 9 adeno-associated vectors selected from a set. Also disclosed is a method of using an immunobiological preparation, characterized by the fact that the preparation is administered intramuscularly in the form of a mixture of adeno-associated vectors of serotype 9 or each adeno-associated vector of serotype 9, which is part of the combination, is administered separately. USE - Biotechnology. ADVANTAGE - Creation of an immunobiological preparation for treating and preventing HIV infection based on various combinations of recombinant genetic vectors based on adeno-associated virus serotype 9 expressing broadly neutralizing anti-HIV-1 antibodies. 8 cl, 11 dwg, 11 tbl |
| IPC 分类号 | A61K-035/761 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16214 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | BOGOSLOVSKAYA E V,GLAZKOVA D V,BELUGIN B V,et al. SET OF RECOMBINANT GENETIC VECTORS CODING BROADLY NEUTRALIZING ANTIBODIES AGAINST HIV-1, IMMUNOBIOLOGICAL PREPARATION FOR TREATMENT AND PREVENTION OF HIV INFECTION AND METHOD OF ITS APPLICATION. RU2833072-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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