Microfluidic device used for nanoencapsulation of messenger ribonucleic acid into lipid nanoparticles includes microfluidic cartridge, elastic sealing element, and upper and lower adapter plates including two inlet ports and one outlet port
	GINTSBURG A L; LOGUNOV D YU; GUSHCHIN V A; DOLGUSHIN S A; SHALAEV P V; VERDIEV B I O; IVANOV R A; KLEIMENOV D A; BYKONIA E N; MAZUNINA E P; DZHARULLAEVA A SH; POCHTOVYI A A; SINIAVIN A E; USACHEV E V; VASINA D V; KUZNETSOVA N A; DMITRIEV S E; IVANOV I A; TUTYKHINA I L; REMIZOV T A; ZAKHAROVA A A; SEMIKHIN A S; GOSUDAREV A I; EGOROVA D A; SHCHERBININ D N; TOKARSKAYA E A; LUBENETS N L; PRUSS I V
	2024-06-18
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2024-06-18
专利号	RU230085-U1
成果简介	NOVELTY - Microfluidic device comprises: a microfluidic cartridge (1) in which a microstructure of channels (2) with two inlet through holes and one outlet through hole is formed, thus providing nanoencapsulation of mRNA into lipid nanoparticles by the microfluidic mixing method; an elastic sealing element; an upper adapter plate (10); and a lower adapter plate (4) including two inlet ports and one outlet port intended for connecting tubes for introducing reagents and removing the product. The device contains pins (3) for positioning the microfluidic cartridge relative to the lower adapter plate, screws that tighten the adapter plates and seal the cartridge channels, where the microfluidic cartridge and the sealing element are made of polymeric materials that have high bioinertness and chemical resistance. USE - The device is useful for nanoencapsulation of mRNA into lipid nanoparticles (claimed). ADVANTAGE - The device allows mixing reagents at flow rates of at least 100 ml/minutes for at least 4 hours, without depressurization of the cartridge and violation of its geometry and without changing the specified characteristics of the nanocomponents of the output product. DESCRIPTION OF DRAWING(S) - The figure shows a schematic view of microfluidic device. 1Microfluidic cartridge 2Microstructure of channels 3Pins 4Lower adapter plate 10Upper adapter plate
IPC 分类号	C12M-003/00 ; C12P-019/34
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/16209
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	GINTSBURG A L,LOGUNOV D YU,GUSHCHIN V A,et al. Microfluidic device used for nanoencapsulation of messenger ribonucleic acid into lipid nanoparticles includes microfluidic cartridge, elastic sealing element, and upper and lower adapter plates including two inlet ports and one outlet port. RU230085-U1[P]. 2024.

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