| METHOD FOR EARLY DIAGNOSIS OF SECONDARY IMMUNODEFICIENCY IN CHILDREN UNDER CONDITIONS OF EXCESSIVE ALUMINIUM CONTAMINATION OF BIOLOGICAL MEDIA | |
| 2024-06-24 | |
| 专利权人 | MEDICAL & PREVENTIVE TECHNOLOGIES MANAGI (MEDI-Non-standard) |
| 申请日期 | 2024-06-24 |
| 专利号 | RU2833545-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to preventive medicine, human ecology and paediatrics, and can be used for early diagnosis of secondary immunodeficiency in children under conditions of excessive aluminium contamination of biological media. Aluminium content is determined in the child's urine. Blood is analysed for level of specific immunoglobulin G (IgG) to aluminium and level of T-regulatory lymphocytes CD127-. Polymerase chain reaction is used to determine polymorphism of the FAS cell death receptor gene and the TLR4 toll-like receptor gene. If the content of aluminium in the child's urine is 0.012 mg/dm3 and more, if the level of IgG to aluminium is not less than 1.2 times higher than norm of 0.0-0.1 standard units, with a decrease of not less than 1.1 times the level of CD127- compared to the lower limit of the norm equal to 1.2%, as well as in the presence of the CC genotype of the FAS C14405T (rs1159120) gene and the GG genotype of the TLR4 A8595G (rs1927911) gene, the child is diagnosed with developing secondary immunodeficiency in conditions of excessive aluminium contamination of biological media. USE - Medicine. ADVANTAGE - Method provides early diagnosis of secondary immunodeficiency in children with excessive aluminium contamination of biological media by determining toxicological, laboratory and genetic indicators of the child’s health. 2 cl, 2 tbl, 2 ex |
| IPC 分类号 | C12Q-001/6806 ; C12Q-001/6827 ; C12Q-001/686 ; C12Q-001/6883 ; G01N-033/49 ; G01N-033/58 ; G01N-033/68 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16131 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | MEDICAL & PREVENTIVE TECHNOLOGIES MANAGI (MEDI-Non-standard) |
| 推荐引用方式 GB/T 7714 | DOLGIKH O V,ALEKSEEV V B,KAZAKOVA O A,et al. METHOD FOR EARLY DIAGNOSIS OF SECONDARY IMMUNODEFICIENCY IN CHILDREN UNDER CONDITIONS OF EXCESSIVE ALUMINIUM CONTAMINATION OF BIOLOGICAL MEDIA. RU2833545-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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