| METHOD FOR DESTRUCTION OF BACTERIAL BIOFILM FORMED ON PIG SKIN IN EX VIVO MODEL | |
| 2024-06-26 | |
| 专利权人 | AS RUSSIA PHYS INST (ASPH-Soviet Institute) |
| 申请日期 | 2024-06-26 |
| 专利号 | RU2835154-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine and can be used for destruction of pathogenic biofilms formed by bacteria of various types on skin and other surfaces of human body. Bacterial biofilm formed on pork skin in ex vivo model is destroyed, its surface is coated with a layer of copper or silver nanoparticles. Said copper or silver nanoparticles are transferred from a donor substrate, which is transparent for infrared laser radiation, on the surface of which there is a silver or copper film with thickness of at least 20 nm, which is located at distance of 0.8-1.2 mm above the porcine skin fragment. As a result of scanning said donor substrate with a laser beam with wavelength of 1064 nm, pulse duration of 120 ns, pulse repetition frequency 20 kHz at pulse energy 0.2 mJ, scanning speed 1000 mm/s and laser spot size 30 mcm. USE - Medicine. ADVANTAGE - Invention provides destruction, as well as potential increase in the safety of the effect of nanoparticles on living tissue with further targeted use of the method in vivo as a result of reduced toxicity of the obtained nanoparticles. 1 cl, 3 dwg, 1 tbl, 1 ex |
| IPC 分类号 | A61K-033/34 ; A61K-033/38 ; A61L-002/08 ; A61P-017/02 ; B82B-001/00 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/16100 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | AS RUSSIA PHYS INST (ASPH-Soviet Institute) |
| 推荐引用方式 GB/T 7714 | KUDRYASHOV S I,NASTULIAVICHUS A A,TOLORDAVA E R,et al. METHOD FOR DESTRUCTION OF BACTERIAL BIOFILM FORMED ON PIG SKIN IN EX VIVO MODEL. RU2835154-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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