METHOD FOR FORMING IMMUNE SURVEILLANCE SYSTEM FOR TUMOUR CELLS IN MAMMAL BODY
	GINTSBURG A L; KAPRIN A D; LOGUNOV D YU; GUSHCHIN V A; TUKHVATULIN A I; TUKHVATULINA N M; KOZLOVA S R; ANTONOVA N P; SHIDLOVSKAIA E V; VERDIEV B I O; IVANOV R A; KLEIMENOV D A; BYKONIA E N; MAZUNINA E P; DZHARULLAEVA A SH; POCHTOVYI A A; SINIAVIN A E; USACHEV E V; VASINA D V; KUZNETSOVA N A; DMITRIEV S E; IVANOV I A; TUTYKHINA I L; REMIZOV T A; ZAKHAROVA A A; SEMIKHIN A S; GOSUDAREV A I; SHCHERBININ D N; TOKARSKAYA E A; LUBENETS N L
	2024-06-29
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2024-06-29
专利号	RU2828654-C1
成果简介	NOVELTY - Invention relates to immunology and oncology. A method for inducing an immune response to tumour cells in a mammalian body is developed, involving a) detection of differences in gene signatures of tumour and normal cells, including prioritization by level of expression of mutant gene, uniqueness, agretopicity; b) synthesis of a set of DNA templates, each of which contains an open reading frame encoding one of the detected gene signatures or an open reading frame encoding from 2 to 80 detected gene signatures; c) synthesis of a set of mRNA based on the obtained set of DNA templates, wherein the mRNA contains the sequence SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:8 at 5'-end; an open reading frame encoding from 1 to 80 tumour gene signatures; sequence SEQ ID NO: 6 or SEQ ID NO: 7 at 3'-end; d) obtaining lipid nanoparticles containing synthesized mRNA; e) introducing the obtained lipid nanoparticles into the mammalian body. USE - Medicine. ADVANTAGE - Invention enables the immune system to efficiently detect and destroy tumour cells; invention can be used in therapy of patients with oncological diseases of various aetiologies. 1 cl, 4 dwg, 1 tbl, 8 ex
IPC 分类号	A61K-039/00 ; A61P-035/00 ; C12Q-001/68
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/16045
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	GINTSBURG A L,KAPRIN A D,LOGUNOV D YU,et al. METHOD FOR FORMING IMMUNE SURVEILLANCE SYSTEM FOR TUMOUR CELLS IN MAMMAL BODY. RU2828654-C1[P]. 2024.

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