| METHOD FOR DIAGNOSING CONGENITAL CARDIAC ANOMALIES IN CHILDREN UNDER CONDITIONS OF EXCESSIVE NICKEL CONTAMINATION | |
| 2024-08-14 | |
| 专利权人 | MEDICAL & PREVENTIVE TECHNOLOGIES MANAGI (MEDI-Non-standard) |
| 申请日期 | 2024-08-14 |
| 专利号 | RU2836533-C1 |
| 成果简介 | NOVELTY - Invention refers to medicine, namely to paediatrics, and can be used for diagnosing congenital cardiac anomalies in children under conditions of excessive nickel contamination. Child’s blood is examined for nickel, creatine phosphokinase (CPK) and Annexin V-FITC+7AAD-. MTHFR and IL-6 genes genotypes are analysed by polymerase chain reaction. When nickel content is 20% and more compared to the upper limit of the reference level equal to 7.5 mcg/dm3, at CPK level of 239 units/l and more, with content of Annexin V-FITC+7AAD- 11.8% and more, in the presence of the genotype CC of the MTHFR C677T (rs1801133) gene and genotype CC of the IL-6 G174C (rs1800795) gene, congenital heart anomalies are diagnosed in a child under conditions of excessive nickel contamination. USE - Medicine. ADVANTAGE - Method provides accurate assessment of the effect of nickel on manifestation of congenital heart anomalies in children with excessive nickel contamination by determining the child’s blood nickel content, CPK level, Annexin V-FITC+7AAD- and genotypes MTHFR and IL-6. 2 cl, 2 tbl, 2 ex |
| IPC 分类号 | C12Q-001/6806 ; C12Q-001/6827 ; C12Q-001/686 ; C12Q-001/6876 ; C12Q-001/6883 ; G01N-030/72 ; G01N-033/52 ; G01N-033/58 |
| 国家 | 俄罗斯 |
| 专业领域 | 生物科学 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/15458 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | MEDICAL & PREVENTIVE TECHNOLOGIES MANAGI (MEDI-Non-standard) |
| 推荐引用方式 GB/T 7714 | DOLGIKH O V,ZAYTSEVA N V,ALEKSEEV V B,et al. METHOD FOR DIAGNOSING CONGENITAL CARDIAC ANOMALIES IN CHILDREN UNDER CONDITIONS OF EXCESSIVE NICKEL CONTAMINATION. RU2836533-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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