CATIONIC LIPID FOR DELIVERY OF NUCLEIC ACIDS INTO MAMMALIAN CELLS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF
	GINTSBURG A L; LOGUNOV D YU; GUSHCHIN V A; IVANOV R A; KOVALCHUK S I; TUKHVATULINA N M; KLEIMENOV D A; DZHARULLAEVA A SH; BYKONIA E N; MAZUNINA E P; IVANOV I A; KARP O E; VERDIEV B I O; POCHTOVYI A A; SHCHERBININ D N; USACHEV E V; VASINA D V; TUKHVATULIN A I; DMITRIEV S E; KUZNETSOVA N A; SINIAVIN A E; KOZLOVA S R; ANTONOVA N P; SHIDLOVSKAIA E V; TUTYKHINA I L; EGOROVA D A; REMIZOV T A; ZAKHAROVA A A; BOGDANOV A YU; KARPOV A P; SEMIKHIN A S; GOSUDAREV A I; TOKARSKAYA E A; LUBENETS N L; VEREVEIKO I R; KOMIAKOVA M E; EROKHOVA A S; UNGUR A S
	2024-08-30
专利权人	FEDERAL STATE BUDGETARY INST (FSBI-C)
申请日期	2024-08-30
专利号	RU2836309-C1
成果简介	NOVELTY - Group of inventions refers to medicine and pharmaceutics, namely to cationic lipids of structural formula (1) for nucleic acid delivery, a method for production thereof, their use for delivery of nucleic acids into mammalian cells in vitro and in vivo. Disclosed versions of cationic lipids, as well as lipid particles based thereon, can be used to develop preventive and therapeutic preparations based on RNA. In general formula (1), where R is primary alkyl groups with chain length from 7 to 17 carbon atoms, Q is linker group of structure -C(O)NH-, or -C(O)O-, or -OC(O)-, X is an amino group or a dimethylamino group. USE - Medicine. ADVANTAGE - Use of the group of inventions provides the creation of a cationic lipid which is capable of forming lipid particles in a complex with nucleic acid and providing its effective delivery both in vitro and in vivo. 13 cl, 14 dwg, 4 tbl, 25 ex
IPC 分类号	A61K-047/18 ; A61K-009/127 ; C07C-229/08 ; C07C-229/12 ; C07C-237/52 ; C07D-207/16 ; C07D-211/16
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/15306
专题	中国科学院新疆生态与地理研究所
作者单位	FEDERAL STATE BUDGETARY INST (FSBI-C)
推荐引用方式 GB/T 7714	GINTSBURG A L,LOGUNOV D YU,GUSHCHIN V A,et al. CATIONIC LIPID FOR DELIVERY OF NUCLEIC ACIDS INTO MAMMALIAN CELLS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF. RU2836309-C1[P]. 2024.

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