Preparing voriconazole-loaded nano vesicular gel having antifungal activity against Candida Albicans, involves adding gelling agent (Poloxamer 407) to voriconazole-phospholipid complex-loaded nanovesicles, stirring and adding poloxamer 407 slowly to nanovesicle formulation ensuring uniform mixing
	KAUSHIK D; SHARMA S
	2024-09-04
专利权人	KAUSHIK D (KAUS-Individual) ; SHARMA S (SHAR-Individual)
申请日期	2024-09-04
专利号	IN202411067031-A
成果简介	NOVELTY - Preparing voriconazole-loaded nano vesicular gel using phospholipid (egg-lecithin) and poloxamer 407 as nanocarrier and gelling agent, involves preparing the voriconazole-loaded gel directly adding gelling agent i.e. 20 wt.% Poloxamer 407 to the voriconazole-phospholipid complex-loaded nanovesicles (VCZ-EL-NVs), keeping 20 ml VCZ-EL-NVs on a magnetic stirrer, and adding poloxamer 407 slowly to the nanovesicle formulation ensuring uniform mixing, after the completion of the addition of the gelling agent into VCZ-EL-NVs, keep the liquid formulation containing the gelling agent at room temperature to obtain gel, where the voriconazole-phospholipid complex-loaded nanovesicles are prepared by the solvent evaporation method, dissolving VCZ and EL in 10 ml methanol, mixing the resultant solutions and keep for stirring, evaporating the solvent, hydrating the resultant complex with 20 ml distilled water containing 0.2 wt.% polysorbate 80, homogenizing, ultrasonicating the solution. USE - Method for preparing voriconazole-loaded nano vesicular gel using phospholipid (egg-lecithin) and poloxamer 407 as nanocarrier and gelling agent, having antifungal activity against Candida Albicans(claimed), used for treating vaginal candidiasis. The antifungal activity of voriconazole-loaded nano vesicular gel was tested against Candida Albicans. The result showed that voriconazole-loaded nano vesicular gel exhibited MIC value of 0.05776 µg/mL. ADVANTAGE - The gel has high bioavailability, a smooth, opaque appearance, uniform texture, and nongreasy feel without grittiness and coalescence. DETAILED DESCRIPTION - Preparing voriconazole-loaded nano vesicular gel using phospholipid (egg-lecithin) and poloxamer 407 as nanocarrier and gelling agent, involves preparing the voriconazole-loaded gel directly adding gelling agent i.e. 20 wt.% Poloxamer 407 to the voriconazole-phospholipid complex-loaded nanovesicles (VCZ-EL-NVs), keeping 20 ml VCZ-EL-NVs on a magnetic stirrer at 1000 rpm, and adding poloxamer 407 slowly to the nanovesicle formulation ensuring uniform mixing, after the completion of the addition of the gelling agent into VCZ-EL-NVs, keep the gel in the refrigerator for 30 minutes for proper mixing, after 30 minutes refrigeration, keep the liquid formulation containing the gelling agent at room temperature (37℃) to obtain gel, where the voriconazole-phospholipid complex-loaded nanovesicles are prepared by the solvent evaporation method, dissolving certain weights of VCZ and EL (molar ratio 4:5 mM) in 10 ml methanol respectively, mixing the resultant solutions and keep for stirring on a magnetic stirrer for 2 hours at 74℃ at 500 rpm, evaporating the solvent by using a rotary evaporator to obtain VCZ-EL complex, further hydrating the resultant complex with 20 ml distilled water containing 0.2 wt.% Polysorbate 80, homogenizing the solution for 5 minutes at 8000 rpm, ultrasonicating the solution for 4 minutes to obtain voriconazole-phospholipid complex (VCZ-EL) loaded nanovesicles.
IPC 分类号	A61K-031/4196 ; A61K-047/10 ; A61K-047/24 ; A61K-009/127 ; A61P-015/02 ; B82Y-030/00 ; B82Y-040/00 ; B82Y-005/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/15259
专题	中国科学院新疆生态与地理研究所
作者单位	1.KAUSHIK D (KAUS-Individual) 2.SHARMA S (SHAR-Individual)
推荐引用方式 GB/T 7714	KAUSHIK D,SHARMA S. Preparing voriconazole-loaded nano vesicular gel having antifungal activity against Candida Albicans, involves adding gelling agent (Poloxamer 407) to voriconazole-phospholipid complex-loaded nanovesicles, stirring and adding poloxamer 407 slowly to nanovesicle formulation ensuring uniform mixing. IN202411067031-A[P]. 2024.

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