Biomarker panel used in kit for differentiating individuals with chronic obstructive pulmonary disease in sample, and measuring level of biomarkers using biomarker panel via sensor, comprises nine biomarkers selected from Immunoglobulin Lambda Variable 3-25, and Immunoglobulin Heavy Constant Delta
	SRIVASTAVA S; SHARMA G
	2024-09-12
专利权人	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
申请日期	2024-09-12
专利号	IN202421069095-A
成果简介	NOVELTY - Biomarker panel comprises nine biomarkers selected from Immunoglobulin Lambda Variable 3-25 (IGLV3-25), Immunoglobulin Heavy Constant Delta (IGHD), peroxiredoxin-6 (PRDX6), cluster of differentiation 84 (CD84), RAB11A, PRKCSH, intercellular adhesion molecule 3 (ICAM3), progranulin (GRN), pleckstrin (PLEK), H3.3 Histone A (H3-3A), Elastase, Neutrophil Expressed (ELANE), Solute Carrier Family 4 Member 1 (SLC4A1), Cytidine Deaminase (CDA), Serpin Family A Member 11 (SERPINA11), Immunoglobulin Heavy Constant Epsilon (IGHE), H1.2 Linker Histone, Cluster Member (H1-2), phosphoglycerate mutase 1 (PGAM1), matrix metalloproteinase-8 (MMP8), secretoglobin family 1A member 1 (SCGB1A1), Matrix Gla protein (MGP), insulin-like growth factor binding protein 5 (IGFBP5), actin-related protein 2/3 complex subunit 4 (ARPC4), chloride intracellular channel protein 1 (CLIC1), and glucose phosphate isomerase (GPI). USE - Biomarker panel used in kit for differentiating individuals with chronic obstructive pulmonary disease (COPD) in a sample, and measuring the level of the biomarkers using biomarker panel via sensor. ADVANTAGE - The kit facilitates early identification and management of COPD. The biomarker panel facilitates the early detection of COPD for those who are at high risk of developing COPD but currently are asymptomatic with normal lung function, where differential expression levels of IGLV3-25, IGHD, PRDX6, CD84, RAB11A, PRKCSH, ICAM3, GRN, and PLEK against one reference is indicative of an asymptomatic smoker with normal lung function, or individual with COPD, where reference is a healthy individual or asymptomatic smoker. DETAILED DESCRIPTION - Biomarker panel comprises nine biomarkers selected from Immunoglobulin Lambda Variable 3-25 (IGLV3-25), Immunoglobulin Heavy Constant Delta (IGHD), peroxiredoxin-6 (PRDX6), cluster of differentiation 84 (CD84), RAB11A, PRKCSH, intercellular adhesion molecule 3 (ICAM3), progranulin (GRN), pleckstrin (PLEK), H3.3 Histone A (H3-3A), Elastase, Neutrophil Expressed (ELANE), Solute Carrier Family 4 Member 1 (SLC4A1), Cytidine Deaminase (CDA), Serpin Family A Member 11 (SERPINA11), Immunoglobulin Heavy Constant Epsilon (IGHE), H1.2 Linker Histone, Cluster Member (H1-2), phosphoglycerate mutase 1 (PGAM1), matrix metalloproteinase-8 (MMP8), secretoglobin family 1A member 1 (SCGB1A1), Matrix Gla protein (MGP), insulin-like growth factor binding protein 5 (IGFBP5), actin-related protein 2/3 complex subunit 4 (ARPC4), chloride intracellular channel protein 1 (CLIC1), glucose phosphate isomerase (GPI), SH3 Domain Binding Glutamate Rich Protein Like (SH3BGRL), Leukotriene A4 Hydrolase (LTA4H), Solute Carrier Family 3 Member 2 (SLC3A2), proteinase 3 (PRTN3), myeloid cell nuclear differentiation antigen (MNDA), triose phosphate isomerase (TPI1), insulin-like growth factor binding protein 1 (IGFBP1), ras-related nuclear protein (RAN), Cyclase Associated Actin Cytoskeleton Regulatory Protein 1 (CAP1), Lymphocyte Antigen 6 Family Member G6F (LY6G6F), H4 Clustered Histone 1 (H4C1), and phosphatidylethanolamine binding protein 1 (PEBP1). INDEPENDENT CLAIMS are included for: Method for differentiating individuals with chronic obstructive pulmonary disease from healthy, and asymptomatic smokers, which involves: (1) obtaining a sample from an individual; measuring the differential expression level of nine biomarkers; and (2) quantifying the differential expression level in said sample against one reference to differentiate individuals with chronic obstructive pulmonary disease (COPD), where the reference is selected from a healthy individual, or an asymptomatic smoker; Kit for differentiating healthy individuals, asymptomatic smokers, and individuals with chronic obstructive pulmonary disease (COPD) in a sample, which comprises one reagent for detecting and quantifying the biomarkers, and a user manual; and Sensor (100), which comprises a memory (104), and a detection module (102) coupled with the memory, configured to differentiating individuals with chronic obstructive pulmonary disease (COPD), from healthy, and asymptomatic smokers, where the detection module comprises the biomarker panel. DESCRIPTION OF DRAWING(S) - The drawing shows block diagram of a sensor. 100Sensor 101Input module 102Detection module 103User interface 104Memory
IPC 分类号	C12Q-001/68 ; C12Q-001/6813 ; C12Q-001/6825 ; G01N-033/53 ; G01N-033/68
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/15171
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
推荐引用方式 GB/T 7714	SRIVASTAVA S,SHARMA G. Biomarker panel used in kit for differentiating individuals with chronic obstructive pulmonary disease in sample, and measuring level of biomarkers using biomarker panel via sensor, comprises nine biomarkers selected from Immunoglobulin Lambda Variable 3-25, and Immunoglobulin Heavy Constant Delta. IN202421069095-A[P]. 2024.

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