| Making chloroethylamino-substituted derivatives of aminoalkyl esters of indole-carboxylic acid, having antitumor activity involves e.g. reacting ethyl-bromo-(bromomethyl)-methoxy-methyl-1H-indole-carboxylate with bis(chloroethyl)amine | |
| 2024-09-20 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2024-09-20 |
| 专利号 | RU2024127831-A |
| 成果简介 | NOVELTY - Obtaining chloroethylamino-substituted derivatives of aminoalkyl esters of indole-3-carboxylic acid i.e. 1-methyl-2-[di(2-chloroethyl)aminomethyl]-3-carbethoxy-5-methoxy-6-bromoindole (I) and 1-cyclohexyl-2-[di(2-chloroethyl)aminomethyl]-3-carbethoxy-5-methoxy-6-bromoindole (II) as active agent possessing antitumor activity. USE - The method is useful for obtaining chloroethylamino-substituted derivatives of aminoalkyl esters of indole-3-carboxylic acid, possessing antitumor activity. No biological data given. ADVANTAGE - The method produces chloroethylamino-substituted derivatives of aminoalkyl esters of indole-3-carboxylic acid which is stable and upon parenteral administration inhibits the growth of neoplasms of many histogenesis, without inducing significant negative toxic effects. DETAILED DESCRIPTION - Obtaining chloroethylamino-substituted derivatives of aminoalkyl esters of indole-3-carboxylic acid i.e. 1-methyl-2-[di(2-chloroethyl)aminomethyl]-3-carbethoxy-5-methoxy-6-bromoindole of formula (I) and 1-cyclohexyl-2-[di(2-chloroethyl)aminomethyl]-3-carbethoxy-5-methoxy-6-bromoindole of formula (II) as active agent possessing antitumor activity, comprises (a) reacting ethyl 5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylate of formula (III) to obtain ethyl 5-methoxy-1,2-dimethyl-1H-indole-3-carboxylate of formula (IV), (b) reacting (IV) to obtain ethyl 6-bromo-5-methoxy-1,2-dimethyl-1H-indole-3-carboxylate of formula (V), reacting (V) to obtain ethyl 6-bromo-2-(bromomethyl)-5-methoxy-1-methyl-1H-indole-3-carboxylate of formula (VI), and (c) reacting (VI) in the presence of bis(2-chloroethyl)amine to obtain (I). |
| IPC 分类号 | C07D-209/42 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/15096 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | FILIMONOVA M V,SOLDATOVA O V,SURINOVA V I,et al. Making chloroethylamino-substituted derivatives of aminoalkyl esters of indole-carboxylic acid, having antitumor activity involves e.g. reacting ethyl-bromo-(bromomethyl)-methoxy-methyl-1H-indole-carboxylate with bis(chloroethyl)amine. RU2024127831-A[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论