| Radiotherapeutic treatment of primary multiple kidney tumors, includes installation of R-contrast markers under ultrasound control in each tumor and the calculation of a dosimetric plan for radiation treatment and then performing CT marking | |
| 2024-09-24 | |
| 专利权人 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 申请日期 | 2024-09-24 |
| 专利号 | RU2024128164-A |
| 成果简介 | NOVELTY - Radiotherapeutic treatment of primary multiple kidney tumors, includes installation of R-contrast markers under ultrasound control in each tumor and the calculation of a dosimetric plan for radiation treatment, where after the installation of R-contrast markers, 7-10 days later, CT marking is performed with the contouring of each tumor of the kidney and critical organs e.g. liver, spleen, spinal cord, stomach, duodenum, colon, pancreas, ribs with subsequent transfer to the MultiPlan planning system, when positioning the patient in the system, select the parameters e.g. treatment anatomy-body, set of trajectory templates, 1path-body, tracking method, tracking of fiducials with breathing synchronization (Synchrony), collimator type, fixed collimator and include the contour correction ray tracing algorithm function, directed towards the patient's body surface, with relatively large diameter beams passing through heterogeneous tissue, select sequential optimization. USE - The method is useful for radiotherapeutic treatment of primary multiple kidney tumors. No biological data given. ADVANTAGE - None given. DETAILED DESCRIPTION - Radiotherapeutic treatment of primary multiple neoplasms of the kidney, includes installation of R-contrast markers under ultrasound control in each tumor and the calculation of a dosimetric plan for radiation treatment, where after the installation of R-contrast markers, 7-10 days later, CT marking is performed with the contouring of each tumor of the kidney and critical organs e.g. liver, spleen, spinal cord, stomach, duodenum, colon, pancreas, ribs with subsequent transfer to the MultiPlan planning system, when positioning the patient in the system, select the parameters e.g. treatment anatomy-body, set of trajectory templates, 1path-body, tracking method, tracking of fiducials with breathing synchronization (Synchrony), collimator type, fixed collimator and include the contour correction ray tracing algorithm function, directed towards the patient's body surface, with relatively large diameter beams passing through heterogeneous tissue, select sequential optimization, which includes a series of individual optimization stages carried out in a certain sequence, set the optimization scenario maximum values of monitor units for each beam, for each position of the manipulator - 750-1300 IU for the entire course, respectively for the target and each organ at risk, the minimum and maximum dose and dose volume restrictions are set PTV 1, minimum dose 46 Gy PTV 2, minimum dose 46 Gy right kidney, excluding PTV-maximum dose 18.5 Gy per 30% of the volume, liver-maximum dose 15 Gy per 20% of volume, spinal cord of 9 Gy maximum dose at the point, spleen 6 Gy maximum dose at the point, stomach maximum dose 13 Gy per 10 cm3volume, colon 16 Gy maximum dose at a point, maximum dose 15 Gy at 20 cm3volume, duodenum 22 Gy maximum dose at a point, maximum dose 11 Gy at 10 cm3volume, pancreas maximum dose 13 Gy per 10 cm3volume, ribs maximum dose 27 Gy per 1 cm3volume, skin 14 Gy maximum dose, dose at a distance of 5 mm from the edge of PTV-44 Gy, dose at a distance of 60 mm from the edge of PTV-13.5 Gy, block between PTV1 and PTV2 to minimize the dose to normal kidney tissue between targets, block the maximum volume covered by a dose of 22 Gy 10%, in this case, for each stage of optimization, target and relaxation values are selected for each volume optimization of the minimum dose of PTV (OMI)-46 Gy, relaxation value 0.2 Gy, optimization of the minimum dose of GTV1 (OMI)-50 Gy, relaxation value 0.2 Gy, optimization of the minimum dose of GTV2 (OMI)-50 Gy, relaxation value 0.2 Gy, optimization of the coating for the shell at a distance of 14 mm from the edge of the PTV-31 Gy, relaxation value 1 Gy, optimization of the coating for the shell at a distance of 40 mm from the edge of the PTV-15 Gy, relaxation value 1 Gy, optimization of the coating for the shell at a distance of 60 mm from the edge of the PTV-10 Gy, relaxation value 1 Gy, in this case, the collimator size is selected based on the size of each target and after successful optimization, the beam reduction function is used to reduce the total number of beams in the treatment plan having reduced the number of beams to a minimum cut-off level above 60 IU, proceed to the evaluate stage to perform a high-resolution dose calculation and to save the plan as suitable for treatment and after the final calculation, the dose is scaled to cover 95% of the total PTV volume of 46.8 Gy, while in order to minimize the dose to healthy renal parenchyma, an additional block structure is introduced between PTV1 and PTV2, which allows isodose decoupling and reducing the dose between targets, then, a 46.8 Gy SOD is delivered to the only right kidney in 3 daily fractions of 15.6 Gy, and during each radiation treatment session, the position of the target is monitored in real time by the position of the R-contrast markers (fiducials) with breathing synchronization (synchrony) in the automatic mode of the cyberKnife linear accelerator. |
| IPC 分类号 | A61B-006/03 ; A61B-006/08 ; A61M-036/02 ; G16H-020/40 ; G16H-040/60 |
| 国家 | 俄罗斯 |
| 专业领域 | 信息技术 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/15070 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | FEDERAL STATE BUDGETARY INST (FSBI-C) |
| 推荐引用方式 GB/T 7714 | CHERNICHENKO A V,PLAVNIK R N,KAPRIN A D,et al. Radiotherapeutic treatment of primary multiple kidney tumors, includes installation of R-contrast markers under ultrasound control in each tumor and the calculation of a dosimetric plan for radiation treatment and then performing CT marking. RU2024128164-A[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论