Gel-based formulation for oral wound healing, exhibiting anti-inflammatory, analgesic, and antimicrobial activities, treating stress ulcers, mucosal trauma from dental appliances, comprises combination of cannabis leaf extract enriched with cannabidiol, and enzyme complex of trypsin and chymotrypsin
	DAS S; SINGH A; KUMAR G; MENON I; JHA K; MANDAL Y
	2024-11-20
专利权人	KALINGA IND TECHNOLOGY INST (KALI-Non-standard)
申请日期	2024-11-20
专利号	IN202431090079-A
成果简介	NOVELTY - Gel-based formulation comprises a combination of cannabis leaf extract enriched with cannabidiol (CBD), and an enzyme complex of trypsin and chymotrypsin. USE - Gel-based formulation for oral wound healing, exhibiting anti-inflammatory, analgesic, and antimicrobial activities, treating stress ulcers, mucosal trauma from dental appliances, tobacco-related inflammatory reactions, periodontal infections, periapical infection-related dental pain, and post-surgical oral wounds (all claimed). No biological data given. ADVANTAGE - The gel-based formulation utilizes the cannabis leaf extract that regulates proinflammatory and profibrotic cytokines by inhibiting reactive oxygen species (ROS) production and scavenging them, thus preventing lipid peroxidation and promoting cellular homeostasis, utilizes trypsin and chymotrypsin enzyme complex that provides anti-inflammatory, anti-edematous, fibrinolytic, antioxidant, and anti-infective effects, enhancing the wound healing process by modulating inflammatory responses and reducing tissue edema, utilizes hemp seed oil that provides a medium for sustained release of active ingredients to the affected site, ensuring prolonged therapeutic action for oral mucosal wounds. The gel-based formulation utilizes combination of cannabidiol and the trypsin-chymotrypsin enzyme complex that creates a novel wound healing agent not found in current commercial products, offering a synergistic effect that enhances the healing process and reduces pain, can be produced in different delivery systems, including but not limited to oral patches, for targeted and sustained application in the oral cavity, utilizes cannabidiol that acts on cannabinoid receptor 2 (CB2) and adenosine A2A receptors, reducing levels of interleukin (IL)-6, cyclooxygenase (COX), tumor necrosis factor receptor (TNF), and inducible nitric-oxide synthase (iNOS), contributing to its anti-inflammatory and antioxidant properties, facilitates direct absorption and higher bioavailability when applied to the oral mucosa, resulting in efficient delivery of the active components for wound healing, utilizes the synergistic combination of CBD and the enzyme complex that promotes rapid wound healing by accelerating tissue repair and reducing inflammation without known adverse side effects.
IPC 分类号	A61K-031/05 ; A61K-031/352 ; A61K-036/185 ; A61K-009/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14479
专题	中国科学院新疆生态与地理研究所
作者单位	KALINGA IND TECHNOLOGY INST (KALI-Non-standard)
推荐引用方式 GB/T 7714	DAS S,SINGH A,KUMAR G,et al. Gel-based formulation for oral wound healing, exhibiting anti-inflammatory, analgesic, and antimicrobial activities, treating stress ulcers, mucosal trauma from dental appliances, comprises combination of cannabis leaf extract enriched with cannabidiol, and enzyme complex of trypsin and chymotrypsin. IN202431090079-A[P]. 2024.

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