Nanoparticle system for sustained delivery of therapeutic agent in treating chronic periodontitis, enabling localized treatment of periodontitis by reducing microbial load, and mitigating inflammation, comprises quercetin-loaded chitosan nanoparticles formulated through ionic gelation
	AREKAR A K; TUNGARE K; SAKHARAM R P; MOOLYA N N
	2024-11-21
专利权人	AREKAR A K (AREK-Individual) ; TUNGARE K (TUNG-Individual) ; SAKHARAM R P (SAKH-Individual) ; MOOLYA N N (MOOL-Individual) ; SMBT DENTAL COLLEGE & HOSPITAL (SMBT-Non-standard)
申请日期	2024-11-21
专利号	IN202421090706-A
成果简介	NOVELTY - Nanoparticle system comprises quercetin-loaded chitosan nanoparticles formulated through ionic gelation, where the quercetin is encapsulated within a chitosan matrix, and nanoparticles exhibiting antimicrobial, antioxidant, and antiinflammatory properties, configured to deliver quercetin in a controlled and sustained release manner to periodontal tissues, where the chitosan matrix facilitates the retention and adhesion of nanoparticles to the periodontal pocket, allowing prolonged therapeutic action and biodegradability within the biological environment. USE - Nanoparticle system for sustained delivery of therapeutic agent in treating chronic periodontitis, enabling localized treatment of periodontitis by reducing microbial load, mitigating inflammation, and promoting periodontal tissue regeneration, and as an adjunctive treatment to scaling and root planing (all claimed). Test details are described, but no result given. ADVANTAGE - The nanoparticles are formulated in a gel form for application into the periodontal pocket, providing ease of administration and ensuring the localized, prolonged release of quercetin. The chitosan matrix is biodegradable, enabling safe and natural degradation within the periodontal environment without leaving harmful residues, while simultaneously supporting tissue regeneration.
IPC 分类号	A61K-031/353 ; A61K-047/36 ; A61K-009/00 ; A61P-029/00 ; B82Y-005/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14442
专题	中国科学院新疆生态与地理研究所
作者单位	1.AREKAR A K (AREK-Individual) 2.TUNGARE K (TUNG-Individual) 3.SAKHARAM R P (SAKH-Individual) 4.MOOLYA N N (MOOL-Individual) 5.SMBT DENTAL COLLEGE & HOSPITAL (SMBT-Non-standard)
推荐引用方式 GB/T 7714	AREKAR A K,TUNGARE K,SAKHARAM R P,et al. Nanoparticle system for sustained delivery of therapeutic agent in treating chronic periodontitis, enabling localized treatment of periodontitis by reducing microbial load, and mitigating inflammation, comprises quercetin-loaded chitosan nanoparticles formulated through ionic gelation. IN202421090706-A[P]. 2024.

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