Composition for exhibiting antibacterial, antioxidant, and anticancer activities, and inducing apoptosis in PA-1 ovarian cancer cell lines, comprises silver nanoparticles synthesized using Macrotyloma uniflorum seed extracts
	PATNAIK S
	2024-11-21
专利权人	UNIV KALINGA IND TECHNOLOGY INST (UYKA-Non-standard)
申请日期	2024-11-21
专利号	IN202431090356-A
成果简介	NOVELTY - Composition comprises silver nanoparticles (AgNPs) synthesized using Macrotyloma uniflorumseed extracts, where the nanoparticles exhibit an average diameter of 91.8 nm, confirmed by particle size analysis. USE - Composition for exhibiting antibacterial, antioxidant, and anticancer activities, and inducing apoptosis in PA-1 ovarian cancer cell lines (all claimed). ADVANTAGE - The composition possesses a distinct surface plasmon resonance band at a peak of 436 nm, utilizes nanoparticles that exhibit a negative zeta potential, enhancing their stability and interaction with cellular membranes, inhibits cell proliferation, exhibits deoxyribo nucleic acid (DNA) damage and apoptosis in ovarian cancer cells as evidenced by fluorescence-assisted cell sorting (FACS) and confocal laser scanning microscopy (CLSM) using 5,5,6,6'-tetrachloro-1,1',3,3' tetraethylbenzimi-dazoylcarbocyanine iodide (JC-1) dye. The composition induces mitochondrial membrane potential disruption, and triggers cell cycle arrest in cancer cells. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for synthesizing silver nanoparticles using Macrotyloma uniflorumseed extracts, comprising: (a) extracting bioactive compounds from Macrotyloma uniflorumseeds; (b) mixing the extract with an aqueous solution of silver nitrate (AgNO3); (c) allowing the mixture to react at room temperature until the color changes from transparent to dark brown, indicating the formation of AgNPs; (d) confirming nanoparticle synthesis using UV-Visible spectrophotometry, with a peak at 436 nm.
IPC 分类号	A23L-033/105 ; A61K-033/38 ; A61P-035/00 ; B82Y-040/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14427
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV KALINGA IND TECHNOLOGY INST (UYKA-Non-standard)
推荐引用方式 GB/T 7714	PATNAIK S. Composition for exhibiting antibacterial, antioxidant, and anticancer activities, and inducing apoptosis in PA-1 ovarian cancer cell lines, comprises silver nanoparticles synthesized using Macrotyloma uniflorum seed extracts. IN202431090356-A[P]. 2024.

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