Composition for anti-cancer activities against ovarian cancer cell lines, and inducing apoptosis, and used for antibacterial activity, comprises silver nanoparticles synthesized using Semecarpus anacardium nut extracts, where silver nanoparticles are capped and stabilized by bioactive compounds
	PATNAIK S; PENCHALANENI J; HARIKA G V S; KOKKANTI R R; LAVUDI K
	2024-11-21
专利权人	UNIV KALINGA IND TECHNOLOGY INST (UYKA-Non-standard)
申请日期	2024-11-21
专利号	IN202431090351-A
成果简介	NOVELTY - Composition comprises silver nanoparticles (AgNPs) synthesized using Semecarpus anacardiumnut extracts, where the silver nanoparticles are capped and stabilized by bioactive compounds present in the Semecarpus anacardiumextract, the composition exhibits an average particle size of 1.4 nm, the nanoparticles have a negative zeta potential of -38.6 mV, indicating stability, the composition contains functional groups such as hydroxyl and carbonyl groups as characterized by fourier transform infrared spectroscopy (FTIR) analysis, which contribute to the reduction and stabilization of the silver nanoparticles. USE - Composition for anti-cancer activities against ovarian cancer cell lines, and inducing apoptosis, and used for antibacterial activity (all claimed). No biological data given. ADVANTAGE - The composition promotes cell cycle arrest at the G0/G1 phase, exhibits free radical scavenging activity, as confirmed through 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays showing up to 56.45% scavenging efficacy at 100 µg/ml concentration, demonstrates in vitro anti-cancer activity against MCF-7 and PA-1 ovarian cancer cell lines, with IC50 values indicative of cytotoxic and anti-proliferative effects, and used as a bio-compatible treatment for inhibiting the growth of cancer cells, showing minimal toxicity to normal cells. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a method for synthesizing silver nanoparticles using Semecarpus anacardium(SA) nut extracts for anti-cancer applications, comprising: (a) preparing a methanolic extract from Semecarpus anacardiumnuts; (b) mixing the methanolic extract with an aqueous silver nitrate solution to initiate nanoparticle synthesis; (c) observing a color change from colorless to brown, indicating successful nanoparticle formation; (d) incubating the reaction mixture and recording the peak absorbance of the nanoparticles at 412-427 nm; (e) characterizing the particle size and zeta potential to ensure stability and proper size distribution of the nanoparticles; (f) confirming the presence of functional groups responsible for reduction and stabilization via FTIR analysis.
IPC 分类号	A61K-031/192 ; A61K-033/00 ; A61K-033/38 ; A61P-035/00 ; C01G-005/00
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14425
专题	中国科学院新疆生态与地理研究所
作者单位	UNIV KALINGA IND TECHNOLOGY INST (UYKA-Non-standard)
推荐引用方式 GB/T 7714	PATNAIK S,PENCHALANENI J,HARIKA G V S,et al. Composition for anti-cancer activities against ovarian cancer cell lines, and inducing apoptosis, and used for antibacterial activity, comprises silver nanoparticles synthesized using Semecarpus anacardium nut extracts, where silver nanoparticles are capped and stabilized by bioactive compounds. IN202431090351-A[P]. 2024.

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