Bromo-2-methylphenylisothiocyanate composition used for wound healing, comprises aniline, triethylamine, carbon disulfide, ethyl acetate, water, sodium bicarbonate, hydrogen peroxide, and potassium bromide
	SINHA U B; BUPESH G; RICHA K; PARTHASARATHY S; GOGOI P P; LONGKUMER P; SINGHA B; WALLING B; BORUAH N
	2024-11-27
专利权人	SINHA U B (SINH-Individual) ; BUPESH G (BUPE-Individual) ; RICHA K (RICH-Individual) ; PARTHASARATHY S (PART-Individual) ; GOGOI P P (GOGO-Individual) ; LONGKUMER P (LONG-Individual) ; SINGHA B (SING-Individual) ; WALLING B (WALL-Individual) ; BORUAH N (BORU-Individual)
申请日期	2024-11-27
专利号	IN202431092998-A
成果简介	NOVELTY - Bromo-2-methylphenylisothiocyanate composition comprises: 5-15 mmol aniline; 25-35 mmol triethylamine; 15-25 mmol carbon disulfide; 5-10 mL ethyl acetate; 5-10 mL water; 4-8 mmol sodium bicarbonate; 2-4 mmol hydrogen peroxide; and 4-8 mmol potassium bromide. USE - Bromo-2-methylphenylisothiocyanate composition used for wound healing (claimed). No biological data given. ADVANTAGE - The composition helps in accelerating tissue regeneration, and achieve complete healing of burn wounds in 21 days or less. DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a process for synthesizing 4-bromo-2-methylphenylisothiocyanate, which involves: (a) mixing 5-15 mmol aniline and 25-35 mmol triethylamine in an ice-cooled mixture; (b) adding 15-25 mmol carbon disulfide dropwise to the mixture to form a dithiocarbamate salt; (c) stirring the reaction mixture at room temperature for 2 hours to allow precipitation of the dithiocarbamate salt; (d) filtering and washing the dithiocarbamate salt with a mixture of ethyl acetate and hexane to remove unreacted aniline and excess triethylamine; (e) drying the resultant dithiocarbamate salt in a vacuum desiccator; (f) forming an ice-cold suspension of 2-4 mmol dithiocarbamate salt in a biphasic solvent system of 5-10 mL ethyl acetate and 5-10 mL water; (g) adding 4-8 mmol sodium bicarbonate and a mixture of 2-4 mmol hydrogen peroxide and 4-8 mmol potassium bromide to the suspension; (h) stirring the suspension for 15-20 minutes to complete desulfurization and precipitation of sulfur; (i) separating the organic layer, drying it over anhydrous sodium sulfate, and concentrating it under reduced pressure; and (j) purifying the product using a short column of silica gel chromatography to obtain 4-bromo-2-methylphenylisothiocyanate.
IPC 分类号	A61P-017/02 ; C07C-265/12
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14349
专题	中国科学院新疆生态与地理研究所
作者单位	1.SINHA U B (SINH-Individual) 2.BUPESH G (BUPE-Individual) 3.RICHA K (RICH-Individual) 4.PARTHASARATHY S (PART-Individual) 5.GOGOI P P (GOGO-Individual) 6.LONGKUMER P (LONG-Individual) 7.SINGHA B (SING-Individual) 8.WALLING B (WALL-Individual) 9.BORUAH N (BORU-Individual)
推荐引用方式 GB/T 7714	SINHA U B,BUPESH G,RICHA K,et al. Bromo-2-methylphenylisothiocyanate composition used for wound healing, comprises aniline, triethylamine, carbon disulfide, ethyl acetate, water, sodium bicarbonate, hydrogen peroxide, and potassium bromide. IN202431092998-A[P]. 2024.

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