Endotyping chronic adenoiditis by taking venous blood from child during diagnosis, determining level of transforming growth factor beta-1, interferon-gamma, interleukin-5, interleukin-1beta and TNF-alpha by enzyme immunoassay and diagnosing endotype based on depending on determined marker level
	ZATULIVETROVA D O; IRINA S V; BADYAN A S
	2024-11-27
专利权人	ZATULIVETROVA D O (ZATU-Individual)
申请日期	2024-11-27
专利号	RU2024135563-A
成果简介	NOVELTY - Method for endotyping chronic adenoiditis in children involves at the stage of diagnosing the disease, taking venous blood from the child, determining the level of transforming growth factorβ -1 (TGFβ -1), interferon-γ (IFN-γ ), interleukin-5 (IL-5), IL-1β , and TNF-α by enzyme immunoassay and diagnosing as one of four endotypes depending on the level of the determined markers, where e.g. (a) endotype 1, bacterial is diagnosed with a TGF-β 1 level of 51.5-65.53 pg/ml or with a TGF-β 1 level of 30.35-51.5 pg/ml in combination with an IL-1β level of more than 20.45 pg/ml, (b) endotype 2, viral is diagnosed with a TGF-β 1 level of ≤ 8.33 pg/ml and an IFN-γ level of more than 47.09 pg/ml, or (c) endotype 3, hypertrophic variant is diagnosed with a TGF-β 1 level of more than 93.1 pg/ml or with a TGF-β 1 level of 65.43-93.1 pg/ml in combination with a specific TNF-α indicator level. USE - The method is useful for endotyping chronic adenoiditis in children. DETAILED DESCRIPTION - Method for endotyping chronic adenoiditis in children involves at the stage of diagnosing the disease, taking venous blood from the child, determining the level of transforming growth factorβ -1 (TGFβ -1), interferon-γ (IFN-γ ), interleukin-5 (IL-5), IL-1β , and TNF-α by enzyme immunoassay and diagnosing as one of four endotypes depending on the level of the determined markers, where (a) endotype 1, bacterial is diagnosed with a TGF-β 1 level of 51.5-65.53 pg/ml or with a TGF-β 1 level of 30.35-51.5 pg/ml in combination with an IL-1β level of more than 20.45 pg/ml, (b) endotype 2, viral is diagnosed with a TGF-β 1 level of ≤ 8.33 pg/ml and an IFN-γ level of more than 47.09 pg/ml, (c) endotype 3, hypertrophic variant is diagnosed with a TGF-β 1 level of more than 93.1 pg/ml or with a TGF-β 1 level of 65.43-93.1 pg/ml in combination with a specific TNF-α indicator level, and (d) endotype 4, allergic variant is diagnosed with a TGF-β 1 level of 8.33-30.35 pg/ml in combination with an IL-5 indicator of more than 14.45 pg/ml or with a TGF-β 1 level of 30.35-51.5 pg/ml in combination with an IL-1β indicator of ≤ 20.45 pg/ml.
IPC 分类号	G01N-033/50
国家	俄罗斯
专业领域	生物科学
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14345
专题	中国科学院新疆生态与地理研究所
作者单位	ZATULIVETROVA D O (ZATU-Individual)
推荐引用方式 GB/T 7714	ZATULIVETROVA D O,IRINA S V,BADYAN A S. Endotyping chronic adenoiditis by taking venous blood from child during diagnosis, determining level of transforming growth factor beta-1, interferon-gamma, interleukin-5, interleukin-1beta and TNF-alpha by enzyme immunoassay and diagnosing endotype based on depending on determined marker level. RU2024135563-A[P]. 2024.

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