New phenylpyrazole-based ligand for transition metals to catalyze reactions for cross-electrophile coupling aryl triflate and aryl bromide
	MAITI D; MAITI S; GHOSH P; RAJA D
	2024-12-16
专利权人	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
申请日期	2024-12-16
专利号	IN202421099412-A
成果简介	NOVELTY - Phenylpyrazole-based ligand (I) is new. USE - Phenylpyrazole-based ligand for transition metals to catalyze reactions for C(sp2) C(sp2) cross-electrophile coupling an aryl triflate and aryl bromide (claimed). ADVANTAGE - The ligands as a portion of the catalyst system in efficient C(sp2) C(sp2) cross-electrophile coupling reactions of aryl bromides and aryl triflates, to improve yield of the desired cross-coupled product, where catalysts systems comprises the transition metal ligands for the coupling reactions of aryl halide and aryl triflate. DETAILED DESCRIPTION - Phenylpyrazole-based ligand of formula (I) is new. R1, R2=hydrogen, halogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, and -OR;R3=hydrogen, methyl, tent-butyl;R=alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, and -(CH2)m-R4;(R)2 signifies two R functional groups=alkyl, cycloalkyl, aryl, heteroaryl; and R4=alkyl, cycloalkyl, aryl, heteroaryl, aralkyl and heteroaralkyl; and m=0-8. INDEPENDENT CLAIMS are included for: A method for preparing the ligands, which involves: reacting the dialkoxy aryl bromide having formula (VII) with pyrazole coupling partners having formula (VIII) using a copper catalyzed C-N bond formation in presence of a solvent, adding a regent selected from Cy2PCl, iPr2PCl or Chlorodiphenylphosphine (Ph2PCl) to the reaction mixture of the C-N coupled product from (b) in a solvent to obtain ligands. A method for C(sp2) C(sp2) cross-electrophile coupling an aryl triflate and aryl bromide in presence of ligand of formula (I), a base and a solvent.
IPC 分类号	A61K-031/397 ; A61K-031/4155 ; A61K-031/496 ; A61K-031/5377 ; A61K-031/553
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/14043
专题	中国科学院新疆生态与地理研究所
作者单位	INDIAN INST TECHNOLOGY BOMBAY (IITB-C)
推荐引用方式 GB/T 7714	MAITI D,MAITI S,GHOSH P,et al. New phenylpyrazole-based ligand for transition metals to catalyze reactions for cross-electrophile coupling aryl triflate and aryl bromide. IN202421099412-A[P]. 2024.

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