| METHOD OF PRODUCING LIPOSOMAL DOSAGE FORM OF ACETYLCYSTEINE | |
| 2024-12-20 | |
| 专利权人 | UNIV OGAREV MORDOVIA (UYOG-Non-standard) |
| 申请日期 | 2024-12-20 |
| 专利号 | RU2836760-C1 |
| 成果简介 | NOVELTY - Invention refers to pharmacology and medicine, namely to a new type of dosage form of acetylcysteine, which is used as solutions for inhalations and solutions for injections for the purpose of treating bronchopulmonary diseases. Method of producing a liposomal dosage form of acetylcysteine consists in producing a liposomal dosage form by mixing lecithin and cholesterol, dissolving them using chloroform, drying until a lipid film is formed and chloroform completely disappears, further hydration with a solution of acetylcysteine in solution of 0.9 % sodium chloride, homogenisation of the resulting dispersion, purification by dialysis and subsequent assessment of the quantitative content of acetylcysteine, wherein the composition of the dosage form of acetylcysteine, which is both inside the liposomes, and outside the liposomes, wt.%: lecithin 6, cholesterol 0.06, intraliposomal acetylcysteine 1.37, extraliposomal acetylcysteine 8.63, sodium chloride 0.83, deionised water 83.11. USE - Medicine; pharmaceutics. ADVANTAGE - Declared invention enables to reduce the amount of the drug preparation of acetylcysteine, increase the effectiveness of its use due to a new form of drug delivery, having lower toxicity compared to empty liposomes, which can be introduced into the body by different methods (intravenously, intraperitoneally and inhalation), providing its longer action due to the increased half-life of acetylcysteine, which allows to increase the survival rate of patients with acute respiratory distress syndrome and reduce the degree of pulmonary involvement. 1 cl |
| IPC 分类号 | A61K-031/198 ; A61K-009/127 |
| 国家 | 俄罗斯 |
| 专业领域 | 化学化工 |
| 语种 | 英语 |
| 成果类型 | 专利 |
| 文献类型 | 科技成果 |
| 条目标识符 | http://119.78.100.226:8889/handle/3KE4DYBR/13926 |
| 专题 | 中国科学院新疆生态与地理研究所 |
| 作者单位 | UNIV OGAREV MORDOVIA (UYOG-Non-standard) |
| 推荐引用方式 GB/T 7714 | KULIKOV O A,AGEEV V P,PYATAEV N A,et al. METHOD OF PRODUCING LIPOSOMAL DOSAGE FORM OF ACETYLCYSTEINE. RU2836760-C1[P]. 2024. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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