Preparing bioactive extract from Ailanthus excelsa leaves and evaluating its therapeutic potential, comprises grinding dried leaves into fine powder, extracting with hydrochloric acid, evaporating, drying crude extract and stored in room temperature and conducting acute oral toxicity studies
	SINGH P D; KUMAR S; SINGH K; BHARTI R; SINGH M; SAGAR A; KUMAR A; PANDEY V M; SINGH P S
	2024-12-21
专利权人	SINGH P D (SING-Individual) ; KUMAR S (KUMA-Individual) ; SINGH K (SING-Individual) ; BHARTI R (BHAR-Individual) ; SINGH M (SING-Individual) ; SAGAR A (SAGA-Individual) ; KUMAR A (KUMA-Individual) ; PANDEY V M (PAND-Individual) ; SINGH P S (SING-Individual)
申请日期	2024-12-21
专利号	IN202411101648-A
成果简介	NOVELTY - Preparing bioactive extract comprises:(i) collecting and drying Ailanthus excelsaleaves at 25℃ for 7 days, away from direct sunlight; (ii) grinding the dried leaves into fine powder; (iii) extracting the powdered material using hydrochloric acid as the solvent; (iv) evaporating the solvent at 40℃ using rotary evaporator; (v) drying the resultant crude extract in hot air oven at 50℃ for 24 hours; (vi) storing the dried crude extract in sealed containers at room temperature to maintain its stability; and (vii) evaluating the extract therapeutic potential by conducting acute oral toxicity studies and assessing analgesic activity using a hot plate method wherein the extract demonstrates significant dose dependent analgesic efficacy and is non-toxic up to a dose of 2000 mg/kg. USE - Method for preparing bioactive extract from Ailanthus excelsaleaves and evaluating its therapeutic potential for pain management solutions. No biological data given. ADVANTAGE - The bioactive extract Ailanthus excelsaensures high yield and reproducibility, improved therapeutic efficacy, and safe with no adverse effects, confirms safe doses up to 2000 mg/kg and provides significant dose-dependent efficacy at 200 mg/kg and 400 mg/kg, comparable to the standard drug Indomethacin, sustainable, plant-based alternative with effective therapeutic benefits, eco-friendly extraction, stability, and reliability for large-scale applications.
IPC 分类号	A61K-127/00 ; A61K-036/185
国家	印度
专业领域	医药卫生
语种	英语
成果类型	专利
文献类型	科技成果
条目标识符	http://119.78.100.226:8889/handle/3KE4DYBR/13894
专题	中国科学院新疆生态与地理研究所
作者单位	1.SINGH P D (SING-Individual) 2.KUMAR S (KUMA-Individual) 3.SINGH K (SING-Individual) 4.BHARTI R (BHAR-Individual) 5.SINGH M (SING-Individual) 6.SAGAR A (SAGA-Individual) 7.KUMAR A (KUMA-Individual) 8.PANDEY V M (PAND-Individual) 9.SINGH P S (SING-Individual)
推荐引用方式 GB/T 7714	SINGH P D,KUMAR S,SINGH K,et al. Preparing bioactive extract from Ailanthus excelsa leaves and evaluating its therapeutic potential, comprises grinding dried leaves into fine powder, extracting with hydrochloric acid, evaporating, drying crude extract and stored in room temperature and conducting acute oral toxicity studies. IN202411101648-A[P]. 2024.

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